difficile is an anaerobic, toxin producing microorganism known to cause severe diarrhea, pseudomembranous
colitis or toxic megacolon, in patients where normal bacterial flora of the gut has been altered following antibiotic therapy.
Studies have shown that this bacterium is responsible for 10-25% of antibiotic-associated diarrhoea cases, 50-75% of antibiotic-associated colitis cases, and 90-100% of antibiotic-associated pseudomembranous
difficile can lead to more severe complications including pseudomembranous
colitis and toxic megacolon.
Mr Balmain agreed with the medical cause of death given by pathologist Dr Ye Lin Hock - that Mrs Flavell died of pseudomembranous
colitis, caused by clostridium difficile (CDiff) bacteria.
While it is tempting to believe treatment with a broad spectrum antibiotic is preferable, particularly if the causative pathogen has not been identified, the more widely acting the antibiotic, the more likely it will kill off normal bacterial flora and allow superinfections to develop, such as oral or vaginal candidiasis (thrush) or, more seriously, pseudomembranous
colitis (see box 1, p24).
This pattern of bowel wall enhancement has been observed in patients with radiation enteritis, GVHD, ischemic bowel, intramural hemorrhage, vasculitides such as Henoch-Schonlein purpura, and pseudomembranous
4) In addition, there have been isolated reports of cases caused by pseudomembranous
tracheobronchitis secondary to Bacillus cereus infection, (5) as well as a relationship between microwebs and refractory nodules.
colitis has been the hallmark of infection, the clinical presentation of CDI may range from asymptomatic colonization to severe diarrhea, toxic megacolon, perforation and even death.
difficile is a gram-positive bacterium that is a common cause of antibiotic-associated diarrhea and pseudomembranous
These bacteria are part of the commensal intestinal flora in humans, and toxigenic strains of the organism can cause pseudomembranous
colitis, a severe infection of the colon, after normal gut flora have been eradicated in patients who have received antimicrobial drugs.
The risk for CDAD has increased not only by usual factors, as pseudomembranous
colitis (PMC), toxic megacolon and perforations in C.
Colette Donohue, from Crumlin, Co Dublin, died of multi-organ failure when the infection pseudomembranous
colitis took hold.