On examination the eye showed marked diminished vision, corneal oedema, normal or deep anterior chamber containing liquefied lens particles and pseudohypopyon
in severe cases and hypermature Morgagnian cataractous lens in some cases.
Particularly in cases of proptosis accompanied by signs like leukocoria, restricted eye motility, sudden-onset asymmetric eye position, afferent pupil defect, and pseudohypopyon
, malignancies should be seriously considered and must be excluded.
On FAF, increased autofluorescence from the hyperreflective material overlying the RPE was observed from the inferior aspect of the lesion (pseudohypopyon stage, Figure 4(c)).
Material is subsequently deposited under the neurosensory retina (vitelliform stage) and is sometimes accompanied with a neurosensory detachment (pseudohypopyon stage), with abnormalities of the RPE and subsequent thinning of all retinal layers (vitelliruptive and atrophic stages).
Clinical examination signs that should raise concern include leukocoria (white pupil), strabismus, restriction of ocular motility, asymmetric eye position within the orbit, decreased vision, high pressure in the eye, inflammation of the eyelids or conjunctiva, pseudohypopyon (inferior whitish layer in the anterior chamber of tumor cells), vitreous hemorrhage or inflammation, and an afferent pupillary defect.
Other signs of retinoblastoma may include decreased vision, strabismus, redness, pain, high pressure in the eye, cellulitic-like periocular inflammation, pseudohypopyon, and proptosis in late disease .
There was hyphema in the aqueous humor of an anterior chamber in 18 patients (5.2%), pseudohypopyon
was found in 16 (4.5%) patients, and in 6 cases (1.7%) anterior chamber was not visible due to non-transparency of cornea.
(4) In the case of a very late presentation, an enlarging eye, proptosis, secondary glaucoma, orbital cellulitis, unilateral pupil dilatation, heterochromic iridis, spontaneous hyphaema, pseudohypopyon
or blindness can be present.
cataract, hyphaema, pseudohypopyon
Anterior segment examination showed a pseudohypopyon in the left eye (Figure 1).
Anterior diffuse retinoblastoma, a variant of diffuse retinoblastoma, results in 360[degrees] seeding in the area of the vitreous base/ciliary body with an associated anterior chamber pseudohypopyon. (1-3) The diffuse growth pattern results in late clinical diagnoses because there is no retinal mass, and associated tumor seeding may mimic uveitis.
Neovascularization, neovascular glaucoma, hyphema, pseudohypopyon
and vitreous hemorrhage may be observed in advanced cases.