pseudohyponatremia

pseudohyponatremia

 [soo″do-hi″po-nah-tre´me-ah]
a decreased serum sodium concentration that does not correspond to a real hypotonic disorder, i.e., the serum osmolality is normal. It occurs when hyperlipemia increases the serum non-water volume or hyperproteinemia increases the serum non-sodium solute.

pseu·do·hy·po·na·tre·mi·a

(sū'dō-hī'pō-nă-trē'mē-ă),
A low serum sodium concentration due to volume displacement by massive hyperlipidemia or hyperproteinemia; also used to describe the low serum sodium concentration that may occur with high blood glucose.

pseudohyponatremia

Spuriously low sodium levels due to either
1. Intrinsic properties of a Pt sample–eg, hyperglycemia or hyperproteinemia–displacement of plasma water or due to the cationic nature of monoclonal proteins which bind sodium, hyperlipidemia or hyperviscosity or.
2. Analytic factors, which occur when preparing samples for flame photometry or indirect potentiometry Management Both respond to vitamin 1,25–OH2D3.

pseu·do·hy·po·na·tre·mi·a

(sū'dō-hī'pō-nă-trē'mē-ă)
A low serum sodium concentration due to volume displacement by massive hyperlipidemia or hyperproteinemia; also used to describe the low serum sodium concentration that may occur with high blood glucose.
Synonym(s): pseudohyponatraemia.
References in periodicals archive ?
What methods can be used to distinguish pseudohyponatremia from genuine hyponatremia?
Further work-up of the hyponatremia (120 mmol/L) could exclude pseudohyponatremia (serum osmolality: 267 (normal range: 280-300 mmol/kg)) and adrenal insufficiency by an adrenocorticotropin hormone (ACTH) stimulation test (cortisol basal: 919 nmol/L, 30 min after stimulation with 250 [micro]g ACTH: 1137 nmol/L, and 60 min: 1235 nml/L).
The mechanisms for hyponatremia in alcoholics include hypovolemia, pseudohyponatremia due to alcohol-induced hypertriglyceridemia, beer potomania syndrome, and rarely SIADH or cerebral salt wasting.
c) Nephrological side effects: Acute renal failure, hyponatremia and pseudohyponatremia are the main nephrological side effects.
of measurement is termed pseudohyponatremia in the context of physiologically normal sodium levels and pseudonormonatremia when the result masks physiologically increased sodium.
His electrolytes were within normal limits except for a pseudohyponatremia of 133 mEq/dL due to an elevated glucose of 549 mg/dL.
(3,4) Displacement of water in a sample may lead to pseudohyponatremia when electrolytes are measured by indirect methods.
To our knowledge, there is only 1 other report of a PBC patient with a cholesterol concentration >2000 mg/dL (51.7 mmol/L), and it, too, was associated with pseudohyponatremia significant enough to prompt clinical action (5).
The low sodium concentration was found to be a result of pseudohyponatremia, an artificially low measurement of sodium concentration produced by the presence of severe hyperproteinemia.