pseudohypoaldosteronism type 2B

pseudohypoaldosteronism type 2B

An autosomal dominant condition (OMIM:614491) characterised by severe hypertension, hyperkalaemia and sensitivity to thiazide diuretics, which may be due to a chloride shunt in the renal distal tubule. 

Molecular pathology
Defects in WNK4, which encodes a serine-threonine protein kinase that regulates electrolyte homeostasis, cause pseudohypoaldosteronism type IIB.
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