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a congenital abnormality in which an individually is genetically and gonadally of one sex but has significant contradictions in the morphologic criteria of sex, often including ambiguous external genitalia. In female pseudohermaphroditism, the individual is a genetic and gonadal female with partial masculinization such as an enlarged clitoris resembling a penis and labia majora resembling a scrotum. In male pseudohermaphroditism, the individual is a genetic and gonadal male with feminization or incomplete masculinization, including a small penis, perineal hypospadias, and a scrotum that lacks testes. Pseudohermaphroditism is not to be confused with hermaphroditism, in which the individual has both ovarian and testicular tissue.
A state in which the person is of an unambiguous gonadal sex (that is, possesses either testes or ovaries) but has ambiguous external genitalia. Compare: steroid 5α-reductase.
Synonym(s): false hermaphroditism
pseudohermaphroditism/pseu·do·her·maph·ro·dit·ism/ (-her-maf´ro-dīt-izm″) a state in which the gonads are of one sex, but one or more contradictions exist in the morphologic criteria of sex. In female p., the individual is genetically female and has female gonads (ovaries) but has significant male secondary sex characters. In male p., the individual is genetically male and has male gonads (testes) but has significant female secondary sex characters.
Etymology: Gk, pseudes + Hermaphroditos, son of Hermes and Aphrodite
a condition in which a person exhibits the somatic characteristics of both sexes though possessing the physical characteristics of either males (testes) or females (ovaries). Also spelled pseudohermaphrodism. See also ambiguous genitalia, feminization, def. 2, hermaphroditism. pseudohermaphroditic, adj.
pseudohermaphroditismEndocrinology A state in which a person has the gonadal tissue of one sex, but the wiring, plumbing, and/or chassis of the opposite sex. See Female pseudohermaphroditism, Male pseudohermaphroditism. Cf Hermaphroditism, Intersex, Virilization.
Female pseudohermaphroditism A condition affecting a genotypic–46, XX female with ovaries, caused by a relative excess of androgen in utero, resulting in equivocal or masculinized genital duct derivatives, ie external genitalia and/or a male phenotype with genital ambiguity and/or virilization Etiology.
1. Adrenogenital syndrome Defects of 21-hydroxylase, 11-β-hydroxylase or 3-β-hydroxysteroid dehydrogenase, or delta 5-4 isomerase deficiency, resulting in ↑ androgenic intermediates.
2. Maternal ingestion of progestins or androgens and three maternal virilizing tumors–eg, luteoma of pregnancy
Male pseudohermaphroditism, A condition affecting a genotypic–46, XY male with testes, caused by a relative deficiency of androgen in utero, resulting in a phenotypic female with ambiguous genitalia Etiology 1. Gonadal defects Testicular regression syndrome, persistent müllerian duct origin, Leydig cell agenesis and defects in testosterone synthesis 2. End-organ defects Testicular feminization or androgen insensitivity syndrome, incomplete androgen insensitivity syndrome and 5-α reductase deficiency. See Testicular feminization.
A state in which the person is of an unambiguous gonadal sex (i.e., possesses either testes or ovaries) but has ambiguous external genitalia.
Synonym(s): false hermaphroditism.
Synonym(s): false hermaphroditism.
pseudohermaphroditismA congenital abnormality of the GENITALIA in which they resemble those of the opposite sex. The testes and ovaries (gonads) are, however, those of the genetically correct sex.
a state in which the gonads are of one sex but one or more contradictions exist in the morphological criteria of sex. In female pseudohermaphroditism, the individual is a genetic and gonadal female with partial masculinization; in male pseudohermaphroditism, the individual is a genetic and gonadal male with incomplete masculinization. Pseudohermaphroditism is not to be confused with hermaphroditism, in which the individual possesses both ovarian and testicular tissue.