pseudogenes


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Related to pseudogenes: overlapping genes

pseudogenes

The stable and inactive, long-term consequences of earlier mutations that occurred during the process of evolution and so damaged genes as to make them incapable of coding for proteins. Pseudogenes might be considered as analogues of fossils in geology.
References in periodicals archive ?
Both instruments can perform long reads (14 000-40 000 for the PacBio SMRT and 8000-100 000 for the Nanopore), which can overcome issues with pseudogenes and repeat regions and may help with identifying RNA isoforms; however, both have high error rates.
Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified.
However, recent studies have challenged this concept and proposed several different functions for different pseudogenes of unicellular and multicellular organism (Dhar et al.
Differential expression of OCT4 pseudogenes in pluripotent and tumor cell lines.
Nuclear insertion of mitochondrial pseudogenes (numts) represents a cytoplasmic mitochondrial DNA sequence that has naturally been integrated into an organism's nuclear genome over an evolutionary timescale, giving rise to nDNA sequences of mitochondrial origin (Lopez et al.
The gene is highly polymorphic, with more than 100 known allelic variations, and has a nearby pseudogene with very high-sequence homology.
Given the available resources, it was decided to sequence three loci from these individuals and make artifacts from pseudogenes less likely rather than sequence a single locus and include multiple progeny.
Song H, Buhay JE, Whiting MF, Crandall KA (2008) Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified.
Novel reported peptides can represent single amino acid variants, splice variants, gene fusions, RNA editing events, novel open reading frames, translated noncoding RNAs, and pseudogenes, among many others.
Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in the NCF-1 pseudogenes.
Chromosome 13 with the BRCA2 gene spans more than 95 mega bases with about 633 genes and 296 pseudogenes.
This includes pervasive transcription of the genome, conservation of many nonprotein-coding sequences, sequence-dependent functions of RNAs transcribed from introns, pseudogenes, repetitive DNA, functions almost independent of the exact nucleotide sequence, chromatin topology in gene expression and centromere placement, and the light-focusing property of heterochromatin in inverted nuclei.