2009) or even the 18S pseudogenes
suggested above would help to elucidate the population genetic parameters underlying their respective distributions.
When the researchers tested that idea by making more PTENP1 mRNA in cells, PTEN protein levels rose, indicating that the pseudogene
was indeed mopping up microRNAs that would otherwise reduce PTEN production.
1) The abundance of pseudogenes
compared to functional counterparts within the genome of M.
Intrigued, the researchers deduced what the amino acid sequence of the protein might be if the pseudogene
didn't have the flaw.
are naturally occurring genomic sequences that from an evolutionary standpoint were created through reverse transcription of mRNAs and then reinserted at a new genomic location.
Homologous regions, including pseudogenes
, are known issues in sequencing, (24) and repetitive sequences are known to cause problems in mapping short-sequence reads obtained from NGS (25) (Figure, C and D).
Specifically, men with haplogroup I were shown to have decreased expression of 2 genes: the ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene
(PRKY) in macrophages.
We compared the ratio of heteroplasmic nucleotide proportions for both liver and blood samples to confirm that observed mtDNA heteroplasmy was not the result of a nuclear pseudogene
The presence or absence of the putative pseudogene
can be used to distinguish taxa of Symbiodinium among sites, but no correlation occurs between the pseudogene
and the infection status of the sea fan.
g) MACF1, microtubule-actin crosslinking factor 1; HSPE1P8, heat shock 10-kDa protein 1 pseudogene
8; RRAGC, Ras-related GTP binding C; MYCBP, MYC binding protein; GJA9, gap junction protein, alpha 9, 59 kDa; RHBDL2, rhomboid, veinlet-like 2 (Drosophila); SEC22B, SEC22 vesicle trafficking protein homologB(S.
In Sd197 and Ss046 (late lactose-fermenting strains), the key gene, lacZ (encoding b-D-galactosidase) is intact, although lacY (encoding galactose permease) is a pseudogene
Special attention was paid to the exclusion of pseudogene