pseudogene


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pseu·do·gene

(sū'dō-jēn),
1. A sequence of nucleotides that is not transcribed and therefore has no phenotypic effect.
2. An inactive DNA segment that arose by a mutation of a parental active gene.

pseudogene

(so͞o′də-jēn′)
n.
A segment of DNA that resembles a gene but is not functional and usually not transcribed. Pseudogenes often have functional paralogs in the same organism.

pseudogene

[so̅o̅′dōjēn′]
Etymology: Gk, pseudes + genein, to produce
a DNA sequence that resembles a gene and may be derived from one but lacks a genetic function.

pseudogene

a nucleotide sequence, similar to that of a known functional gene, but that is inactive due to the accumulation of MUTATIONS. A pseudogene may result from a tandem DUPLICATION of an existing gene or REVERSE TRANSCRIPTION of the transcript of the gene (so that it lacks the introns and has a POLY(A) TAIL).

pseudogene

a nonfunctional DNA sequence, nearly homologous to a functional gene.
References in periodicals archive ?
2009) or even the 18S pseudogenes suggested above would help to elucidate the population genetic parameters underlying their respective distributions.
When the researchers tested that idea by making more PTENP1 mRNA in cells, PTEN protein levels rose, indicating that the pseudogene was indeed mopping up microRNAs that would otherwise reduce PTEN production.
1) The abundance of pseudogenes compared to functional counterparts within the genome of M.
Intrigued, the researchers deduced what the amino acid sequence of the protein might be if the pseudogene didn't have the flaw.
Processed pseudogenes are naturally occurring genomic sequences that from an evolutionary standpoint were created through reverse transcription of mRNAs and then reinserted at a new genomic location.
Homologous regions, including pseudogenes, are known issues in sequencing, (24) and repetitive sequences are known to cause problems in mapping short-sequence reads obtained from NGS (25) (Figure, C and D).
Specifically, men with haplogroup I were shown to have decreased expression of 2 genes: the ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages.
We compared the ratio of heteroplasmic nucleotide proportions for both liver and blood samples to confirm that observed mtDNA heteroplasmy was not the result of a nuclear pseudogene.
The presence or absence of the putative pseudogene can be used to distinguish taxa of Symbiodinium among sites, but no correlation occurs between the pseudogene and the infection status of the sea fan.
g) MACF1, microtubule-actin crosslinking factor 1; HSPE1P8, heat shock 10-kDa protein 1 pseudogene 8; RRAGC, Ras-related GTP binding C; MYCBP, MYC binding protein; GJA9, gap junction protein, alpha 9, 59 kDa; RHBDL2, rhomboid, veinlet-like 2 (Drosophila); SEC22B, SEC22 vesicle trafficking protein homologB(S.
In Sd197 and Ss046 (late lactose-fermenting strains), the key gene, lacZ (encoding b-D-galactosidase) is intact, although lacY (encoding galactose permease) is a pseudogene (12).