Includes benign and malignant proliferation including pure sarcoma, particularly in cases composed exclusively of spindle cells, leiomyosarcoma, carcinoma with pseudosarcomatous stroma and sarcomas with pseudoepitheliomatous hyperplasia
Histological examination on the epidermis showed extensive multifocal areas of ortho and hyperkeratosis, and parakeratotic pseudoepitheliomatous hyperplasia
and acanthosis (Figure 2D) with intracorneal microabscesses and presence of basophilic filamentous structures that were morphologically consistent with D.
Histology of the resected specimen showed fibrous tissue with chronic inflammation and fibrin deposition, and a nodular portion of focally ulcerated squamous mucosa with pseudoepitheliomatous hyperplasia
, chronic inflammation, extensive fibrin deposition, and fibrinoid necrosis of blood vessels.
in overlying epithelium is well-established phenomenon in GCTs but underlying pathogenesis is still poorly understood.
The histopathological findings of cutaneous chromoblastomycosis consist of acanthosis, pseudoepitheliomatous hyperplasia
, dermal microabscess, chronic granulomatous inflammation, multinucleated foreign body type of giant cells, "sclerotic body"/"copper penny body.
After excision, histopathological examination revealed bundles of spindle cells producing extensive collagen in both radiating and circular pattern in lower dermis with focal pseudoepitheliomatous hyperplasia
in mucosal epithelium and chronic inflammatory infiltrates in submucosa.
The characteristic histological findings consisted of pseudoepitheliomatous hyperplasia
and intraepithelial or dermal microabscess composed of eosinophils, along with focal ulceration, eosinohilic spongiosis and heavy infiltration of eosinophils, lymphocytes and neutrophils in dermis (figures 3 and 4).
The histopathological lesions were suggestive of dysplasia of squamous cell epithelium leading to condition of pseudoepitheliomatous hyperplasia
which is reactive lesion that may arise secondary to trauma or infection.
The patient underwent resection of the skin lesion which showed pseudoepitheliomatous hyperplasia
(Figure 2), presence of the budding yeast with a double-contoured wall (Figures 3,4) and confirmed a diagnosis of a cutaneous blastomycosis.
The differential diagnosis is Crohns disease, ileitis or Backwash ileitis at the stoma, pseudoepitheliomatous hyperplasia
, extensive pseudopolyposis or granulation tissue, pyoderma gangrenosum, and squamous cell carcinoma.
Correlation with clinical findings and history is essential to avoid misdiagnosing HLE as squamous neoplasia or other lichenoid interface dermatitides with pseudoepitheliomatous hyperplasia
Microscopic evaluation of biopsy from gingival tissue showed parakeratinised stratified squamous epithelium with pseudoepitheliomatous hyperplasia
and intraepithelial abscess, as well as abscess penetrating into the surface of epithelium.