pseudocholinesterase


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Related to pseudocholinesterase: atypical pseudocholinesterase

bu·tyr·o·cho·lin·es·ter·ase

(byū'tir-ō-kō'lin-es'ter-ās),
Pseudocholinesterase or plasma cholinesterase.
See also: cholinesterase.

BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.

pseudocholinesterase

A liver and plasma enzyme that rapidly metabolizes succinylcholine, a short-acting–5-10 mins–neuromuscular anesthetic, thereby controlling its duration of action; some people have congenital PChe variants, in which neuromuscular block is prolonged with usual doses of succinylcholine–and identified by determining the 'dibucaine' number; PChe activity may be ↓ in various acquired conditions–eg, liver disease–hepatitis, cirrhosis, metastasis, malnutrition, acute infections, anemia, MIs, CA, pregnancy, cytotoxic drugs, acetylcholinesterase inhibitors, dermatomyositis. See Dibucaine number.

plas·ma chol·ine·ste·rase

(plaz'mă kō'lin-es'tĕr-ās)
A type of cholinesterase found in plasma.
See also: fluoride number
Synonym(s): butyrylcholinesterase, pseudocholinesterase.
References in periodicals archive ?
This was compared with (4) Pleural fluid pseudocholinesterase and (5) Pleural fluid to serum ratio of pseudocholinesterase.
Montgomery, "The relation of oedema to serum protein and pseudocholinesterase levels in the malnourished infant," Archives of Disease in Childhood, vol.
Low pseudocholinesterase (PChE), high creatinine (Cr), low Glasgow Coma Scale (GCS) scores and long hospitalization durations were all found to be poor prognostics in MV patients.
This study evaluates the significance of analysing serum cholinesterase (pseudocholinesterase) activity in assessing severity, correlating with clinical course and to predict the outcome in organophosphorous poisoning.
At the end of anesthesia, anticholinesterase drugs such as neostigmine are recommended to reverse the residual neuromuscular block, which has a high incidence rate and can lead to critical respiratory events.[sup][1],[2] Cholinesterase can be divided into two categories: acetylcholinesterase (AChE) and pseudocholinesterase. In the neuromuscular junction (NMJ), all of the cholinesterase present is AChE.[sup][3] Anticholinesterase drugs decrease acetylcholine hydrolysis by inhibiting the activity of AChE and thus, improve the concentration of acetylcholine in the NMJ to overcome the effects of muscle relaxants; therefore, their mechanism of reversal is indirect [sup][4] and their antagonistic actions are theoretically related to the activity of AChE in the NMJ.
Patients with atypical variants of pseudocholinesterase with deficient enzymatic activity may require mechanical ventilation and close monitoring following administration of this muscle relaxant.
BuChE is also known as pseudocholinesterase as its capability to hydrolyse both ACh and BuCh at different frequencies (Forget et al., 2002; Khan et al., 2008).
(1) Butyrylcholinesterase, also called pseudocholinesterase, has drawn growing interest in human medicine and is used as a target in Alzheimer's disease (16,17) and Parkinson disease treatment.
Agarwal, "Prognostic and diagnostic value of serum pseudocholinesterase, serum aspartate transaminase, and serum alinine transaminase in malignancies treated by radiotherapy," Journal of Cancer Research and Therapeutics, vol.