pseudo-von Willebrand's disease

pseudo-von Willebrand's disease

Platelet-type von Willebrand disease–vWD An AD condition similar to type IIB vWD, with moderately severe Sx Lab ↑ Bleeding time, ↓ von Willebrand factor–vWF and factor VIII levels, ↑ ristocetin-induced platelet aggregation, absence of large vWF multimers and presence of the same multimers in platelets Pathogenesis Unknown; may involve platelet glycoprotein IB Management Cryoprecipitate. Cf Von Willebrand's disease.
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6] However, desmopressin is contraindicated in type 2 and pseudo-von Willebrand's disease because it can increase platelet aggregation and cause thrombocytopenia.