Matsumura, et al., Update on the potential significance of
psammoma bodies in lung adenocarcinoma from a modern perspective, Histopathology 72 (4) (2018 Mar) 609-618.
The result showed
psammoma bodies and some heterocyst.
The entire nodule was frozen, and sections showed small, tightly packed tubules and nests of epithelioid cells in a fibrous background notable for many
psammoma bodies (Figure 1).
Calcifications are basophilic in centre surrounding eosinophilic border resembling
psammoma bodies. It also showed multiple sinusoidal blood-filled spaces devoid of endothelial lining and surrounded by fibrocellular stroma.
It was considered to be an encapsulated variant of papillary carcinoma due to similar nuclear features, presence of
psammoma bodies, immunohistochemistry profile and RET/PTC translocation.
Occasionally, metastases to the breast demonstrate features that lead the pathologist to a correct diagnosis, such as cells with nuclear grooves, intranuclear inclusions, powdery chromatin and
psammoma bodies as seen in our case.
Also,
psammoma bodies found in the Pap smear are suggestive of gynaecologic malignancy, and more detailed examination is required.5
Numerous
psammoma bodies, squamous metaplasia, and marked sclerosis were the criteria used to diagnose the diffuse sclerosing variant of PTC (DSVPTC) [14].
Histopathological investigations of the mass showed a cystic neoplasm composed of various mature tissue components including skin, pilosebaceous glands, well-developed respiratory and gastric epithelium, and glial tissue with numerous
psammoma bodies. Based on pathological studies the final diagnosis was confirmed as mature type IV SCT.
Psammamatous melanotic schwannoma is circumscribed, heavily pigmented with
psammoma bodies, tumour cells being S-100 positive and CD34 negative.
Characteristic
psammoma bodies and nuclear inclusions were also found (Figure 2).
Foamy macrophages and rare
psammoma bodies occurred in the core of the papillae.
