Matsumura, et al., Update on the potential significance of psammoma bodies
in lung adenocarcinoma from a modern perspective, Histopathology 72 (4) (2018 Mar) 609-618.
The result showed psammoma bodies
and some heterocyst.
The entire nodule was frozen, and sections showed small, tightly packed tubules and nests of epithelioid cells in a fibrous background notable for many psammoma bodies
Calcifications are basophilic in centre surrounding eosinophilic border resembling psammoma bodies
. It also showed multiple sinusoidal blood-filled spaces devoid of endothelial lining and surrounded by fibrocellular stroma.
It was considered to be an encapsulated variant of papillary carcinoma due to similar nuclear features, presence of psammoma bodies
, immunohistochemistry profile and RET/PTC translocation.
Occasionally, metastases to the breast demonstrate features that lead the pathologist to a correct diagnosis, such as cells with nuclear grooves, intranuclear inclusions, powdery chromatin and psammoma bodies
as seen in our case.
Also, psammoma bodies
found in the Pap smear are suggestive of gynaecologic malignancy, and more detailed examination is required.5
Numerous psammoma bodies
, squamous metaplasia, and marked sclerosis were the criteria used to diagnose the diffuse sclerosing variant of PTC (DSVPTC) .
Histopathological investigations of the mass showed a cystic neoplasm composed of various mature tissue components including skin, pilosebaceous glands, well-developed respiratory and gastric epithelium, and glial tissue with numerous psammoma bodies
. Based on pathological studies the final diagnosis was confirmed as mature type IV SCT.
Psammamatous melanotic schwannoma is circumscribed, heavily pigmented with psammoma bodies
, tumour cells being S-100 positive and CD34 negative.
Characteristic psammoma bodies
and nuclear inclusions were also found (Figure 2).
Foamy macrophages and rare psammoma bodies
occurred in the core of the papillae.