Calcifications are basophilic in centre surrounding eosinophilic border resembling psammoma bodies
It was considered to be an encapsulated variant of papillary carcinoma due to similar nuclear features, presence of psammoma bodies
, immunohistochemistry profile and RET/PTC translocation.
3) PRCC CCPRCC Morphology Architecture Papillary Papillary, tubulocystic Cytology Basophilic or Clear eosinophilic Nuclear grade Low-high Low Helpful features Psammoma bodies
, Subnuclear foamy macrophages vacuoles Immunohistochemistry AMACR + -- CD10 + -- CK7 + + RCC Ma + -- Molecular Chromosomal gains 7, 12, 16, Variable, 17, 20 limited data Chromosomal losses Y Abbreviations: AMACR, [alpha]-methyl-acyl-coenzyme A;CCPRCC, clear cell papillary renal cell carcinoma; CCRCC, clear cell renal cell carcinoma; CK7, cytokeratin 7;PRCC, papillary renal cell carcinoma; RCC Ma, renal cell carcinoma marker; VHL, von Hippel-Lindau; +, positive expression of marker; -, no expression of marker.
Caption: Figure 3: Microscopically, diffusely scattered tumor aggregates, extensive fibrosis, marked lymphocytic infiltration with formation of lymphoid follicles, and abundant psammoma bodies
(a) were evident against a background of Hashimoto's thyroiditis (b) (Hematoxylin & Eosin stain x40).
6) Concentric calcified deposits (Liesegang rings) that resemble psammoma bodies
are formed in the amyloid material.
Nuclear pseudoinclusions and psammoma bodies
, which are characteristic histologic features of meningiomas, are not observed in HPCs.
6,11 Frequent calcifications in the form of psammoma bodies
or dystrophic calcification may be present.
A pathologist reported that the tissue was a benign serous papillary rumor with psammoma bodies
The stroma presented fibroblastic reaction and were accompanied by psammoma bodies
The presence of psammoma bodies
in a cervical cytology smear has long been thought to be associated with gynecologic malignancies, but a retrospective review of 400,000 smears collected during routine screening suggests they may be an incidental finding in an asymptomatic population.
As gynecologists, we worry about psammoma bodies
, because they are frequently associated with ovarian serous papillary carcinomas as well as other .
malignancies," he said at the annual meeting of the Pacific Coast Obstetrical and Gynecological Society But studies that linked 60% of smears containing psammoma bodies
to cancer generally included samples from women with malignant background cytology or abnormal symptoms such as postmenopausal bleeding, he noted.