However, the studies that linked 60% of smears containing psammoma
bodies to cancer generally included samples from women with malignant background cytology or abnormal symptoms, he noted.
The risk of malignancy is actually very low when you have psammoma
bodies present on a Pap smear, assuming the patient is asymptomatic, she has an unremarkable physical examination, and the background cytology is normal," Dr.
Transitional or mixed tumors are characterized by a whirling pattern of somewhat spindly elements, and they often contain psammoma
Of type I lesions, 6 had the more traditional histologic findings of meningothelial cells, often in nests and with psammoma
bodies, as well as structures resembling psammoma
bodies but lacking calcification, which they termed collagen bodies.
The prevalence of all the following histologic features was similar in the biologically benign and malignant tumors: papillae, pseudo-papillae, psammoma
bodies, nuclear grooves, nuclear overlap, "orphan Annie" nuclei, nuclear pseudo-inclusions, prominent nucleoli, hypercellularity, colloid scalloping, eosinophilic cytoplasm, mitoses, vascular invasion, cytologic atypia, and nuclear pleomorphism.
43,44) These glandular carcinoids often contain psammoma
bodies but do not produce the somatostatinoma syndrome as reported in patents with pancreatic endocrine D cell tumors.
3) These tumors often show collections of foamy macrophages within the papillary stalks, iron deposition, and psammoma
The identification of psammoma
bodies in the context of a thyroid-type papillary neoplasm is highly supportive in the diagnosis of malignancy.
Nuclear atypia, stratification, mitoses, necrosis, psammoma
bodies, and invasion of surrounding structures are absent.
These tumors often have a pure glandular growth pattern with scattered psammoma
bodies and may be confused with conventional adenocarcinomas.
2 translocation RCC is a carcinoma with mixed papillary and nested/alveolar architecture, composed of cells with clear and/or eosinophilic, granular, voluminous cytoplasm; discrete borders; vesicular chromatin; prominent nucleoli; and the presence of extensive psammoma
bodies (Figures 1 through 4).