pruritus gravidarum

pruritus gravidarum

severe pruritus without associated rash occurring during pregnancy secondary to intrahepatic cholestasis and bile salt retention.

pruritus gravidarum

A condition characterized by intense itching, which occurs in 1:300 pregnancies, beginning in the 3rd trimester, first on the abdomen, later extending to the entire body surface Treatment Antihistamines. See Pregnancy-related conditions. Cf PUPPP.

pru·ri·tus gra·vi·da·rum

(prū-rī'tŭs grav-i-dar'ŭm)
Severe pruritus without associated rash occurring during pregnancy secondary to intrahepatic cholestasis and bile salt retention.
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A bit higher percentage has been reported by other authors.8,13 PUPPP was the commonest specific disorder of pregnancy accounting for 5.6% followed by prurigo of pregnancy in 12 (3.5%) cases and pruritus gravidarum (also known as intrahepatic cholestasis of pregnancy) in 4 (1.2%) cases.
Pruritus gravidarum might be both localized, affecting mainly breasts and abdomen, and generalized.
Intrahepatic cholestasis of pregnancy (ICP), formerly known as pruritus gravidarum, is due to a defect in the excretion of bile salts, causing the excess to deposit on the skin.
Intrahepatic Cholestasis of pregnancy (ICP): (Syn: Obstetric Cholestasis, Pruritus Gravidarum, Icterus Gravidarum, Recurrent Jaundice of Pregnancy, Idiopathic Jaundice of Pregnancy)
(63) ICP being referred to Pruritus Gravidarum (for pruritus without skin changes occurring early in pregnancy and related to atopic diathesis and no cholestasis) and Prurigo Gravidarum (for pruritus associated with PP like skin lesions and associated with cholestasis) lead to much confusion regarding nomenclature.
The commonest pregnancy specific dermatoses was polymorphic eruption of pregnancy accounting for 12 (22.64%) cases, prurigo of pregnancy accounting for 5 (9.43%) cases, pruritic folliculitis of pregnancy accounting for 3 (5.66%) cases followed by single case (0.01%) each of impetigo herpetiformis, pruritus gravidarum and pemphigoid gestationis.
Of the remaining cases of pregnancy specific dermatoses, 1 case each was accounted by pruritus gravidarum, impetigo herpetiformis and pemphigoid gestationis.
(1) The disorder, which is also referred to as obstetric cholestasis and pruritus gravidarum, has no primary skin lesions.
Intrahepatic cholestasis of pregnancy or pruritus gravidarum (seen in 5.3% of patients) is caused by maternal intrahepatic bile secretory dysfunction.Two cases were reported in this study.
45 patients (22.5%) had prurigo of pregnancy, 15 (7.5%) patients had pruritic urticarial papules and plaques of pregnancy (PUPP), 6 patients (3%) had pruritus gravidarum.
Zenon Brzoza et al found PUPP in 3rd trimester in Primigravida's and in women with multiple gestation with incidence of 2.9-16%.9 Incidence of Pruritus Gravidarum was 3%.
Twenty one (48.8%) women had pruritic urticarial papules and plaques of pregnancy, followed by pruritic folliculitis of pregnancy in 11 (25.6%), pruritus gravidarum in 8 (18.6%), prurigo gestations of Besnier in 2 (4.7%) and papular dermatitis in 1 (2.3%) female.