prurigo nodularis


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prurigo

 [proo-ri´go]
any of several itchy skin eruptions in which the characteristic lesion is dome-shaped with a small transient vesicle on top, followed by crusting or lichenification. adj., adj prurig´inous.
prurigo gestatio´nis (prurigo gestationis of Besnier) an extremely pruritic condition of unknown etiology occurring in the third trimester of pregnancy, characterized by the development of tiny crust-covered excoriated papules mainly on the extensor surfaces of the limbs but also found on the upper trunk and other areas of the body, and leaving a postinflammatory residue on resolution of the lesions. It tends to clear after delivery and to recur with subsequent pregnancies.
prurigo mi´tis prurigo of a mild type.
prurigo nodula´ris a form of neurodermatitis, usually occurring on the extremities in middle-aged women, marked by discrete, firm, rough-surfaced, dark brownish-gray, intensely itchy nodules.
prurigo sim´plex papular urticaria.

pru·ri·go no·du·la·'ris

an eruption of hard, dome-shaped nodules (Picker nodules) in the skin caused by rubbing and accompanied by intense itching; occasionally due to mycobacterial infection, the cause is usually unknown.

lichen simplex chronicus

A dermopathy characterised by intensely pruritic nodules on the arms or legs, often with excoriations due to itching.

Aetiology
Idiopathic; it may be associated with Becker's nevus, linear IgA disease, and liver disease, and triggered by internal malignancy, liver or renal failure.

DiffDx
Systemic pruritus—cholestasis, thyroid disease, polycythaemia rubra vera, uraemia, Hodgkin lymphoma, HIV and other immune deficiencies; delusions of parasitosis and other psychiatric conditions.

pru·ri·go no·du·la·ris

(prū-rī'gō nod'yū-lār'is)
An eruption of hard nodules (picker's nodules) in the skin caused by rubbing and accompanied by intense itching.

Hyde,

James N., U.S. dermatologist, 1840-1910.
Hyde disease - an eruption of hard nodules in the skin caused by rubbing and accompanied by intense itching. Synonym(s): picker's nodules; prurigo nodularis
References in periodicals archive ?
Therapeutic hotline: treatment of prurigo nodularis and lichen simplex chronicus with gabapentin.
Despite its name, prurigo nodularis is not just about the itch.
Subsequent histologic examination identified it as prurigo nodularis (Figure 2).
The overall incidence of papulonodular lesions of skin is leprosy (22.67%), erythema nodosum leprosum (20%), cutaneous tuberculosis and trichoepithelioma (8% each), Prurigo Nodularis, actinomycosis and epidermoid cyst (6.67% each), syringoma and granuloma Annulare (5.33% each), basal cell carcinoma and Jessner lymphocytic infiltrate (4% each), and metastatic carcinoma (2.67%).
'A lot of patients who have prurigo nodularis also have associated severe health conditions that need more immediate attention, and many of these PN patients may fall through the cracks,' says dermatologist Shawn Kwatra, M.D., assistant professor of dermatology at the Johns Hopkins University School of Medicine.
"We remain on track to report top-line data from both our Phase 2b/3 PRISM trial of nalbuphine ER in patients with prurigo nodularis and from our Phase 2 trial of nalbuphine ER for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) in the first half of 2020.
- US-based biopharmaceutical company Trevi Therapeutics, Inc has initiated a pivotal clinical trial evaluating Nalbuphine ER in patients with pruritus in prurigo nodularis, the company said.
13, 2018 (HealthDay News) -- African-American patients are more likely to have prurigo nodularis (PN), which is associated with systemic, cardiovascular, and psychiatric comorbidities, according to a study recently published in the Journal of the American Academy of Dermatology.
Objective: To determine the efficacy and safety of thalidomide in treatment of idiopathic prurigo nodularis.
Recent success in the use of neurokinin-1 receptor antagonists, k-opioid receptor modulators, and interleukin (IL)-31 receptor antibodies for treatment of prurigo nodularis (PN) suggests that safer and more effective systemic therapies that provide relief and management of this debilitating chronic skin condition are possible, reported Azam A.
In this descriptive study 13 cases of Psychocutaneous disorders was seen, of which 10 (5%) cases had Lichen simplex chronicus and 3 (1.5%) cases had Prurigo nodularis.
Patients with itching related to prurigo nodularis or atopic disease responded better than those without the conditions, and patients under age 60 obtained greater improvement than older patients.