prozone


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prozone

 [pro´zōn]
in an agglutination or precipitation reaction, the zone of relatively high antibody concentrations within which no reaction occurs. As the antibody concentration is lowered below the prozone, the reaction occurs. This phenomenon may be due simply to antibody excess or it may be due to blocking antibody or to nonspecific inhibitors in serum.

pro·zone

(prō'zōn),
In the case of agglutination and of precipitation, the phenomenon in which visible reaction does not occur in mixtures of specific antigen and antibody because of antibody excess.
Synonym(s): prezone

pro·zone

(prō'zōn)
A phenomenon in which visible agglutination and precipitation do not occur in mixtures of specific antigen and antibody because of antibody excess.
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References in periodicals archive ?
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This was due to the prozone phenomenon, which occurs when a high antibody titer interferes with the formation of an antigen-antibody lattice, which is needed for a positive flocculation test.
Here the purpose of this case report is to highlight "that clinicians should always keep in the corner of their mind the possibility (However rare) of "HOOK EFFECT" or "PROZONE PHENOMENON".
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Other interferences such as the prozone effect and the volume displacement effect are discussed below.