proximal tubule


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to proximal tubule: loop of Henle, Distal tubule

proximal tubule

The first part of the tubular system of a nephron after the Bowman's capsule. It has convoluted and straight segments and is followed by the distal tubule.

proximal tubule

the convoluted tube between the loop of Henle and Bowman's capsule in the vertebrate kidney.
Mentioned in ?
References in periodicals archive ?
(1980) observed iron deposition in renal proximal tubule cells, along with lead-associated histopathological lesions in the kidney, following administration of lead via drinking water to rats.
Erythrophagocytosis of lead-exposed erythrocytes by renal tubular cells: possible role in lead-induced nephrotoxicity
Endocytosis of light chains induces cytokines through activation of NF-[kappa]B in human proximal tubule cells.
Proximal Tubulopathies Associated With Monoclonal Light Chains: The Spectrum of Clinicopathologic Manifestations and Molecular Pathogenesis
Renal Uptake of 99mTc-Dimercaptosuccinic Acid Is Dependent on Normal Proximal Tubule Receptor-Mediated Endocytosis.
Dent's disease type 1 in a boy with severe hyperopia and mental dysfunction: a case report
Villar et al., "Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells," Redox Biology, vol.
Signaling pathways involved in renal oxidative injury: Role of the Vasoactive Peptides and the renal dopaminergic System
We have previously demonstrated that pioglitazone induces NHE3 and AQP1 protein expression in human primary proximal tubule cells [14].
Combined effects of PPAR[gamma] agonists and epidermal growth factor receptor inhibitors in human proximal tubule cells
Kidney of the control rats has shown normal distribution of collagen fibers around Malpigian corpuscles and in brush border of proximal tubules (Figure 6a).
Protective effects of ascorbic acid and zinc against cadmium-induced histopathological, histochemical and cytogenetic changes in rats/Efeitos protetores de acido ascorbico e zinco contra alteracoes histopatologicas, histoquimicas e citogeneticas induzidas por cadmio em ratos
Disintegrated proximal, distal and collecting tubule with pycnotic nuclei in proximal tubule and hematopoietic tissue having clump of cells containing hyper chromatic nuclei were noted at 100 mg/L (Fig.
Histological Alterations in Cyprinus carpio Kidney Due to Sublethal Concentrations of Chromium Hexavalent
It has further been shown that the effect of Ang II to increase proximal tubular chloride and water reabsorption decreases by about 75 per cent following renal denervation and only a very small portion of the Ang II effect ([approximately equal to]25%) can be ascribed to a direct action on Ang II receptors located on proximal tubules (4,8).
Role of norepinephrine & angiotensin II in the neural control of renal sodium & water handling in spontaneously hypertensive rats
Metallothionein isoform 3 and proximal tubule vectorial active transport.
Pleiotropic role of metallothionein-3 (MT-3) in human proximal tubule (HPT) cells differentiation
[6] Last but not least, experimental studies have pointed out that the initial lesion appears to be crystal formation along the brush border of the proximal tubule, with eventual crystal deposition in collecting ducts and papillary interstitium, and eventual tubule obstruction, interstitial inflammation, and fibrosis.
The effect of indomethacin on hyperoxaluria-induced renal tubular epithelial injury/Hiperoksalurinin neden oldugu renal tubuler epiteliyal hasar uzerine indometazinin etkisi
Although the precise biochemical function of [Na.sup.+]-ATPase and its exact physiological role in mammalian intestinal cells remains unraveled, it has been proposed an important role of this enzyme on extracellular volume control by the fine tuning of renal sodium excretion, being a target for autacoids and hormonal selective regulation in proximal tubule cells (20-25).
Solubilizacion y caracterizacion de la ATPasa de Na+ insensible a ouabaina a partir de membranas laterobasales de celulas de intestino delgado
(1999; 2001; 2003a; 2003b; 2005; Zager and Kalhorn, 2000) studied kidney responses to several forms of injury such as renal failure, sepsis, endotoxemia, ischemia-reperfusion or oxidative stress, and they showed that proximal tubule cells undergo some adaptive changes for protection from subsequent hazards.
The nephrotoxicity risk in rats subjected to heavy muscle activity

Medical browser ?
Full browser ?