proximal tubule


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Related to proximal tubule: loop of Henle, Distal tubule

proximal tubule

The first part of the tubular system of a nephron after the Bowman's capsule. It has convoluted and straight segments and is followed by the distal tubule.

proximal tubule

the convoluted tube between the loop of Henle and Bowman's capsule in the vertebrate kidney.
References in periodicals archive ?
(1980) observed iron deposition in renal proximal tubule cells, along with lead-associated histopathological lesions in the kidney, following administration of lead via drinking water to rats.
Endocytosis of light chains induces cytokines through activation of NF-[kappa]B in human proximal tubule cells.
Renal Uptake of 99mTc-Dimercaptosuccinic Acid Is Dependent on Normal Proximal Tubule Receptor-Mediated Endocytosis.
Villar et al., "Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells," Redox Biology, vol.
We have previously demonstrated that pioglitazone induces NHE3 and AQP1 protein expression in human primary proximal tubule cells [14].
Disintegrated proximal, distal and collecting tubule with pycnotic nuclei in proximal tubule and hematopoietic tissue having clump of cells containing hyper chromatic nuclei were noted at 100 mg/L (Fig.
It has further been shown that the effect of Ang II to increase proximal tubular chloride and water reabsorption decreases by about 75 per cent following renal denervation and only a very small portion of the Ang II effect ([approximately equal to]25%) can be ascribed to a direct action on Ang II receptors located on proximal tubules (4,8).
Metallothionein isoform 3 and proximal tubule vectorial active transport.
[6] Last but not least, experimental studies have pointed out that the initial lesion appears to be crystal formation along the brush border of the proximal tubule, with eventual crystal deposition in collecting ducts and papillary interstitium, and eventual tubule obstruction, interstitial inflammation, and fibrosis.
Although the precise biochemical function of [Na.sup.+]-ATPase and its exact physiological role in mammalian intestinal cells remains unraveled, it has been proposed an important role of this enzyme on extracellular volume control by the fine tuning of renal sodium excretion, being a target for autacoids and hormonal selective regulation in proximal tubule cells (20-25).
(1999; 2001; 2003a; 2003b; 2005; Zager and Kalhorn, 2000) studied kidney responses to several forms of injury such as renal failure, sepsis, endotoxemia, ischemia-reperfusion or oxidative stress, and they showed that proximal tubule cells undergo some adaptive changes for protection from subsequent hazards.