(1980) observed iron deposition in renal proximal tubule
cells, along with lead-associated histopathological lesions in the kidney, following administration of lead via drinking water to rats.
Endocytosis of light chains induces cytokines through activation of NF-[kappa]B in human proximal tubule
Renal Uptake of 99mTc-Dimercaptosuccinic Acid Is Dependent on Normal Proximal Tubule
Villar et al., "Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule
cells," Redox Biology, vol.
We have previously demonstrated that pioglitazone induces NHE3 and AQP1 protein expression in human primary proximal tubule
Kidney of the control rats has shown normal distribution of collagen fibers around Malpigian corpuscles and in brush border of proximal tubules
Disintegrated proximal, distal and collecting tubule with pycnotic nuclei in proximal tubule
and hematopoietic tissue having clump of cells containing hyper chromatic nuclei were noted at 100 mg/L (Fig.
It has further been shown that the effect of Ang II to increase proximal tubular chloride and water reabsorption decreases by about 75 per cent following renal denervation and only a very small portion of the Ang II effect ([approximately equal to]25%) can be ascribed to a direct action on Ang II receptors located on proximal tubules
Metallothionein isoform 3 and proximal tubule
vectorial active transport.
 Last but not least, experimental studies have pointed out that the initial lesion appears to be crystal formation along the brush border of the proximal tubule
, with eventual crystal deposition in collecting ducts and papillary interstitium, and eventual tubule obstruction, interstitial inflammation, and fibrosis.
Although the precise biochemical function of [Na.sup.+]-ATPase and its exact physiological role in mammalian intestinal cells remains unraveled, it has been proposed an important role of this enzyme on extracellular volume control by the fine tuning of renal sodium excretion, being a target for autacoids and hormonal selective regulation in proximal tubule
(1999; 2001; 2003a; 2003b; 2005; Zager and Kalhorn, 2000) studied kidney responses to several forms of injury such as renal failure, sepsis, endotoxemia, ischemia-reperfusion or oxidative stress, and they showed that proximal tubule
cells undergo some adaptive changes for protection from subsequent hazards.