proximal renal tubular acidosis


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proximal renal tubular acidosis

Renal tubular acidosis type II Nephrology A disorder caused by a partial defect in the secretion of hydrogen ions in the proximal renal tubule, with ↓ reabsorption of HCO3 from the tubule into the circulation; the net loss of HCO3 from the body results in metabolic acidosis, accompanied by a loss of glucose, amino acids, phosphate, Ca2+, and potassium in the urine; because of the solute loss, water is also dragged out of the body; the metabolic acidosis results in loss of Ca2+ from bone, and ↑ serum Ca2+; excess serum Ca2+ is excreted by the kidneys, causing a loss of total body Ca2+ resulting in osteomalacia or rickets, impaired growth, skeletal deformities, muscle weakness, kidney stones and nephrocalcinosis associated with the excessive excretion of Ca2+ and phosphate through the kidneys
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