challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
He added that it seemed clear she considered that given the severity of the knife wounds to the victim then, but for the provocation, the offence would have been murder.
With geopolitical tension constantly on the rise in northern Africa, the Middle East and Ukraine, Athens will seek out the support from its partners in tackling the latest Turkish provocation in the Aegean.
Participants demonstrated increased aggressive retaliation when provoked by the essay feedback, but only when the provocation could not be clearly interpreted as an insult.
I do think that China could play, and I wish they would play, a larger role in influencing the North Koreans to stop the provocations," he said.
The two ministers agreed to make a strong response to North Korea's provocations and North Korea will be held responsible for all the consequences," Kim said.
The dominant scholarly view holds that provocation is best explained and defended as a partial excuse on the grounds that the killer's inflamed emotional state so compromised his ability to conform his conduct to the demands of reason and law as to render him substantially less blameworthy for his conduct.
Pavlopoulos reiterated that Turkey's provocative stance towards the Republic of Cyprus also constituted provocations against the EU.
But it has refrained from provocations following its launch of an intermediate-range missile over Japan on Sept.
Le ministere palestinien des Affaires etrangeres a demande au quartette de se pencher sur les provocations racistes des milieux officiels israeliens contre le peuple palestinien et ses dirigeants.
Asked to comment on remarks by the government press office's head that "provocations" had taken place on a meeting of Borisov with the Bulgarian expat community in London, she has opined there are "obvious" attempts of "forces and groups" to stir provocations and tarnish the government's reputation.