protoporphyrin


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Related to protoporphyrin: Zinc Protoporphyrin

protoporphyrin

 [pro″to-por´fĭ-rin]
a porphyrin whose iron complex united with protein occurs in hemoglobin, myoglobin, and certain respiratory pigments. It is accumulated and excreted excessively in the feces in erythropoietic protoporphyria and variegate porphyria.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

protoporphyrin

(prō′tō-pôr′fə-rĭn)
n.
A metal-free porphyrin, C34H34N4O4, that combines with ferrous iron to form the heme group in hemoglobin and myoglobin, and with ferric iron to form the hemin group in catalase and some cytochromes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

protoporphyrin

A porphyrin occurring in the course of the synthesis of HAEMOGLOBIN. Excess of this porphyrin, protoporphyria, causes intense itching, swelling and redness of the skin on exposure to sunlight and leads to a strikingly weatherbeaten appearance.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Protoporphyrin

A precursor molecule to the porphyrin molecule.
Mentioned in: Porphyrias
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Mice were divided into four groups of 6 animals each: (1) control normal chow diet; (2) HFD; (3) HFD treated for the last 8 weeks with cobalt protoporphyrin (CoPP) (once/week a dose of 5 mg/100 g, bw); and (4) HFD treated for the last 8 weeks with CoPP and the last 3 weeks with tin mesoporphyrin (SnMP at a dose of 20 mg/100 g BW), an inhibitor of HO activity (twice/week).
Regula et al., "Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX): a pilot study," Neoplasma, vol.
Recent studies have focused on incorporating specific substrates of BOx such as bilirubin, quinones, syringaldazine, and protoporphyrin derivatives such as protoporphyrin IX iron (III) (PPFeIII), protoporphyrin IX dimethyl ester (PPDE), and octaethylporphyrin (OEP) towards appropriate orientation that can be convenient for DET-type electrocatalysis [36].
Ferrochelatase catalyzes the incorporation of iron into protoporphyrin to form heme.
A separate study of 12 healthy adults found that pretreatment with an ablative fractional laser significantly intensifies protoporphyrin IX fluorescence to a larger extent than curettage, microdermabrasion, microneedling, and nonablative fractional laser (JAMA Derm.
The two pigments found in the eggshells were protoporphyrin and biliverdin.
Any genetic defects that impact this process can interrupt the body's ability to produce heme; the decreased heme production leads to a buildup of protoporphyrin components.
Thus more protoporphyrin is formed which is incorporated into the hemoglobin molecule in place of heme.
Cystatin-C, zinc protoporphyrin, urine creatinine clearance testing, ASO antibody titers, anti-DNAase antibody titers, microsomal antibodies, urine microalbumin, urine cultures for crystals and bacterial burdens, for example, are useful in uncovering suspected renal impairment.
In a condition such as IBD, further analyses may be required to confirm IDA, such as reticulocyte hemoglobin content, percentage of hypochromic red blood cells, transferrin saturation index, and zinc protoporphyrin, but these tests are not yet widely available (Table 3).
(1) Assembly of 4 pyrrole rings forms the tetrapyrrole ring protoporphyrin, a precursor of several organic molecules.