protooncogene


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pro·to·on·co·gene

(prō'tō-on'kō-jēn),
A gene conserved long on the evolutionary scale present in the normal human genome, that appears to have a role in normal cellular physiology and is often involved in regulation of normal cell growth or proliferation; as a result of somatic mutations, these genes may become oncogenic; products of protooncognes may have important roles in normal cellular differentiation.

pro·to·on·co·gene

(prō'tō-on'kō-jēn)
A gene in the normal human genome that appears to have a role in normal cellular physiology; involved in regulation of normal cell growth or proliferation; as a result of somatic mutations, these genes may become oncogenic; products of protooncognes may have important roles in normal cellular differentiation.
References in periodicals archive ?
Very early detection of RET protooncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.
Amplification of the protooncogene Her2/neu has been demonstrated to correlate with a higher grade of malignancy and with tumor response to the chemotherapeutic agent Herceptin.
Expression of the c-myc protooncogene in human prostatic carcinoma in benign prostatic hyperplasia.
Induction of protooncogene c-jun by serum growth factors.
9 SCIENCE, a research team led by Jean-Claude Martinou of the Centre Medical Universitaire in Geneva, Switzerland, reports that injections of the human protooncogene, called bcl-2, can prevent the normal death of cultured nerve cells starved of growth factors.
The epithelial cells showed strong positivity for Oscar keratin (OSCAR) (Figure 3, C), AE1/AE3 (Figure 3, D), EMA, and protooncogene c-Kit protein product (c-Kit, also known as CD117), while the myoepithelial cells were positive for S100, calponin (Figure 3, E), and p63 (Figure 3, F).
6] Human genes: KRAS, KRAS proto-oncogene, GTPase; EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; STAT6, signal transducer and activator of transcription 6; MYD88, myeloid differentiation primary response 88; CD79B, CD79b molecule; CCND3, cyclin D3; ALK, anaplastic lymphoma receptortyrosine kinase; ROS1, ROS protooncogene 1, receptor tyrosine kinase; RET, ret proto-oncogene; BRAF, B-Raf protooncogene, serine/threonine kinase; EGFR, epidermal growth factor receptor.
Mitochondrial biogenesis is also controlled by the c-Myc protooncogene.
Expression of the protooncogene bcl-2 in the prostate and its association with emergente of androgen-independent prostate cancer.
Another report showed that SF2/ASF controls cell motility by affecting alternative splicing of the RON protooncogene, leading to the production of the oncogenic ARon isoform, which is found in breast tumors (Ghigna et al.
Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury.