Very early detection of RET protooncogene
mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.
Amplification of the protooncogene
Her2/neu has been demonstrated to correlate with a higher grade of malignancy and with tumor response to the chemotherapeutic agent Herceptin.
Expression of the c-myc protooncogene
in human prostatic carcinoma in benign prostatic hyperplasia.
Induction of protooncogene
c-jun by serum growth factors.
9 SCIENCE, a research team led by Jean-Claude Martinou of the Centre Medical Universitaire in Geneva, Switzerland, reports that injections of the human protooncogene
, called bcl-2, can prevent the normal death of cultured nerve cells starved of growth factors.
The epithelial cells showed strong positivity for Oscar keratin (OSCAR) (Figure 3, C), AE1/AE3 (Figure 3, D), EMA, and protooncogene
c-Kit protein product (c-Kit, also known as CD117), while the myoepithelial cells were positive for S100, calponin (Figure 3, E), and p63 (Figure 3, F).
6] Human genes: KRAS, KRAS proto-oncogene, GTPase; EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; STAT6, signal transducer and activator of transcription 6; MYD88, myeloid differentiation primary response 88; CD79B, CD79b molecule; CCND3, cyclin D3; ALK, anaplastic lymphoma receptortyrosine kinase; ROS1, ROS protooncogene
1, receptor tyrosine kinase; RET, ret proto-oncogene; BRAF, B-Raf protooncogene
, serine/threonine kinase; EGFR, epidermal growth factor receptor.
Mitochondrial biogenesis is also controlled by the c-Myc protooncogene
93 receptor(CSF1R) Tyrosine kinase protooncogene
Expression of the protooncogene
bcl-2 in the prostate and its association with emergente of androgen-independent prostate cancer.
Another report showed that SF2/ASF controls cell motility by affecting alternative splicing of the RON protooncogene
, leading to the production of the oncogenic ARon isoform, which is found in breast tumors (Ghigna et al.
Sequential expression of c-fos protooncogene
, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury.