proton pump inhibitor


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inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

proton pump inhibitor

agents that block the transport of hydrogen ions into the stomach and hence are useful in the treatment of gastric hyperacidity.
Farlex Partner Medical Dictionary © Farlex 2012

proton pump inhibitor

n.
Any of a class of drugs that inhibit gastric acid secretion by interfering with the movement of hydrogen ions across cell membranes and are used mainly to treat peptic ulcers and gastroesophageal reflux disease.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

proton pump inhibitor

An agent—e.g., Prilosec (omeprazole))—used to reduce gastric acid production in patients with dyspepsia, peptic ulcer disease, gastrooesophageal reflux disease, Barrett’s disease, and other conditions.

Adverse effects
Hip fracture, Clostridium difficile infection, hypomagnesaemia and acute interstial nephritis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

proton pump inhibitor

Pharmacology A compound–eg, Prilosec– omeprazole that is better than H2 blockers–eg, Zantac–ranitidine, Tagamet– cimetidine, for treating GERD. See Gastroesophageal reflux disease. Cf H2 blockers.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

pro·ton pump in·hib·i·tor

(prō'ton pŭmp in-hib'i-tŏr)
An agent that blocks the transport of hydrogen ions into the stomach and henceis useful in the treatment of gastric hyperacidity, as observed in ulcer disease.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

proton pump inhibitor

One of a class of drugs that interfere with the action of the proton pump responsible for the synthesis of hydrochloric acid in the parietal cells of the stomach lining. The proton pump is the enzyme H+, K+ -ATPase and this can be blocked by drugs such as OMEPRAZOLE (Losec).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Proton pump inhibitor

One of a group of drugs that acts to reduce the secretion of stomach acid.
Mentioned in: Cox-2 Inhibitors
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

pro·ton pump in·hib·i·tor

(prō'ton pŭmp in-hib'i-tŏr)
Agent that blocks transport of hydrogen ions into stomach and hence are useful in treatment of gastric hyperacidity.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Proton pump inhibitors are intended to be used for a short period of time.
Pajares, "Proton pump inhibitors versus H2-antagonists: a meta-analysis of their efficacy in treating bleeding peptic ulcer," Alimentary Pharmacology & Therapeutics, vol.
Proton pump inhibitors, platelet reactivity, and cardiovascular outcomes after drug-eluting stents in clopidogrel-treated patients: The ADAPT-DES study.
For patients who do not achieve satisfactory therapeutic effects by proton pump inhibitors, Pariet can be given orally at a dose of 10 mg or 20 mg twice-daily for additional 8 weeks.
Proton pump inhibitors have several long-term consequences that most people have the good sense to want to avoid.
Long-term use of proton pump inhibitors increases the risk of kidney disease, (12) blood vessel calcification, (16) nutritional deficiencies,17-19 cardiovascular disease, (3,4) infection (including pneumonia),20-24 diarrhea,25-27 microbial disruption (dysbiosis),28-30 and bone fracture.
A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use.
Are the stomach medications called proton pump inhibitors right for you?
Eisai is currently also conducting a Phase III study in Japan of Pariet as a maintenance therapy for patients with reflux esophagitis resistant to once-daily proton pump inhibitor treatment.
The patent claims, which covers VIMOVO and its PA product candidates, maintained in the opposition proceedings relate to combinations of proton pump inhibitors (PPI) and non-steroidal anti-inflammatory drugs (NSAID), said the company.
Of these 26,000 adults, 12 percent received a proton pump inhibitor with or without an H2-receptor antagonist for at least two years; 4.2 percent of the sample received an [H.sub.2]-receptor antagonist alone.