proton pump


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pump

 [pump]
1. an apparatus for drawing or forcing liquid or gas.
2. to draw or force liquids or gases.
blood pump a machine used to propel blood through the tubing of extracorporeal circulation devices.
breast pump a pump for taking milk from the breast.
calcium pump the mechanism of active transport of calcium (Ca2+) across a membrane, as of the sarcoplasmic reticulum of muscle cells, against a concentration gradient; the mechanism is driven by hydrolysis of ATP.
enteral feeding pump an infusion pump specifically designed for administration of a solution through a feeding tube.
insulin pump see insulin pump.
intra-aortic balloon pump see intra-aortic balloon pump.
muscle pump compression of veins by the contraction of skeletal muscles, forcing blood towards the heart against the flow of gravity; seen particularly in the deep veins of the lower limbs. Called also venous pump.
proton pump a system for transporting protons across cell membranes, often exchanging them for other positively charged ions.
sodium pump (sodium-potassium pump) the mechanism of active transport driven by the energy generated by Na+,K+-ATPase, by which sodium (Na+) is extruded from a cell and potassium (K+) is brought in, so as to maintain the low concentration of sodium and the high concentration of potassium within the cell with respect to the surrounding medium. A high concentration of intracellular potassium is necessary for vital processes such as protein biosynthesis, certain enzyme activities, and maintenance of the membrane potential of excitable cells. Called also Na+-K+ pump.
stomach pump see stomach pump.
venous pump muscle pump.

pro·ton pump

molecular mechanism for the net transport of protons across a membrane; usually involves the activity of an ATPase.

proton pump

An ATP-dependent H+ ion transporter present in the membranes of lysosomes and vacuoles, which maintains a low pH (4.5-5.0) inside these organelles. Proton pumping is also required in the electron transport chain, where an NADH (or FADH) is oxidised to NAD+ (or FAH+), releasing 2 electrons and a proton.

pro·ton pump

(prō'ton pŭmp)
Molecular mechanism for the net transport of protons across a membrane; usually involves the activity of adenosine triphosphatase.

proton pump

a specialized assembly of proteins in a cell membrane which transports protons against a concentration gradient.

proton

an elementary particle of mass number 1, with a positive charge equal to the negative charge of the electron; a constituent particle of every nucleus, the number of protons in the nucleus of each atom of a chemical element being indicated by its atomic number.

proton pump
see sodium pump.
proton pump inhibitor
a class of therapeutic agents which are used to counteract the effects of proton pumps in tissues and organs, particularly used in counteracting gastric hypersecretion and acidity.
References in periodicals archive ?
Key clinical point: Topical steroids seemed to improve mucosal integrity in patients with eosinophilic esophagitis, but proton pump inhibitor therapy did not.
Inappropriate prescribing of proton pump inhibitors in primary care.
Statistical analysis that weighed the impact of numerous fracture risk factors identified 7 that were independently associated with higher fracture risk regardless of whatever other risk factors a person had--white race, cerehrovascular disease or stroke, alcohol-related diagnoses, current proton pump inhibitor use, current protease inhibitor use, higher VACS Index score, and lower body mass index when entering the study group (Figure 1).
Gastric acid suppression by proton pump inhibitors as a risk factor for clostridium difficile-associated diarrhea in hospitalized patients.
FDA's warning and decision to revise the labeling of proton pump inhibitors are based on the Agency's review of several epidemiological studies that reported an increased risk of fractures of the hip, wrist and spine in patients using proton pump inhibitors.
Try a combination of an H2 receptor blocker and a proton pump inhibitor
In a 12-month study of 85 patients who received the Enteryx implant, about two-thirds were able to discontinue use of proton pump inhibitors, and 9% could reduce the dose by at least half, the FDA said.
Zeiger hypothesizes that the guard cell chloroplasts fuel the light-activated proton pump.
However, the continual reduction of stomach acid through medicines like proton pump inhibitors hinders digestion and absorption of key nutrients.
This concomitant therapy consists of a proton pump inhibitor, amoxicillin hydrate (generic name; marketed under two brand names), and either clarithromycin (generic named: marketed under two brand names) or metronidazole (generic name; marketed under one brand name).
While not itself a proton pump, the position and function of this pathway suggest it is an ancestor of the proton pump found in COX.
The Food and Drug Administration issued a warning to physicians and consumers that proton pump inhibitors may increase the risk of hip, wrist, and spine fractures.