The primary endpoint of the study will measure the change in liver fat mass based on magnetic resonance imaging-estimated proton density
fat fraction (MRI-PDFF), an imaging-based biomarker that allows fat mapping of the entire liver.
The company added that the primary efficacy endpoint for the study is absolute change from baseline in hepatic fat fraction measured by Magnetic Resonance Imaging - Proton Density
Fat Fraction (MRI-PDFF) Week 12.
Fat pad edema was recorded as positive, when there was high signal intensity in the superolateral part of infrapatellar fat pad on the proton density
fat-suppressed images (Figure 1).
Hence, the fast protons constitute a small fraction of the total jet proton density
which subsequently produce [gamma]-rays, neutrinos, etc.
From the sagittal position, there was a cortically based lesion with clear osseous margin at the posterior part of tibia with a mixed high signal on proton density
(PD) sequence and a low signal on T1WI at the front of it [Figure 1]c.
(Sagittal Proton Density
Image) shows Bulky ACL (Arrow) having Altered Signal Intensity with Intact Fibres s/o Partial Tear.
In silicon-34, the central proton density
is about half that of a comparable nucleus, the scientists calculated, after taking into account other central orbitals that contain normal numbers of protons.
MR (Figure 1B) axial proton density
with fat saturation demonstrates edema of the os peroneum as the sesamoid courses within the peroneus longus tendon.
Fat-saturated proton density
sequences were obtained in the axial, coronal and sagittal planes.
The imaging studies were performed on either a 1.5T or 3T MR scanner (Siemens Medical) with the following sequences: oblique coronal Turbo Spin Echo (TSE) proton density
(3 mm, TR range/TE range, 2100-2500/25-35) and fat suppressed T2W (3 mm, TR range/TE range 35004000/55-60); oblique sagittal T1W (3 mm, TR range/TE range 450-600/12-15) and fat suppressed T2W (3 mm, TR range/TE range, 3500-4000/55-65); and axial fat suppressed proton density
(3 mm, TR range/TE range, 2100-2500/2537).
(b) Corresponding proton density
weighted fat suppressed sagittal MRI sequence showing the large anteromedial BML (green arrow).