protofibril

protofibril

 [pro″to-fi´bril]
the first elongated unit appearing in formation of any type of fiber.
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Eisai serves as the lead in the co-development of elenbecestat, a BACE inhibitor, and BAN2401, an anti-amyloid beta (Abeta) protofibril antibody, and the companies plan to pursue marketing authorizations for the two compounds worldwide.
(Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") announced today that the investigational oral BACE (beta amyloid cleaving enzyme) inhibitor elenbecestat (development code: E2609) and the investigational anti-amyloid beta (A[beta]) protofibril antibody BAN2401, which are currently being evaluated as treatments for early Alzheimer's disease (AD), have been selected by the ACTC as treatments to be evaluated in upcoming clinical studies targeting primary prevention (A3 Study) and secondary prevention (A45 Study) of AD.
Eisai (ESALY) announced that a global Phase III clinical study of BAN2401, an anti-amyloid beta protofibril antibody, in patients with early Alzheimer's disease has been initiated.
Hypothetically, stress information derived from both motor and nonmotor neurons might be integrated into diverse structures of [alpha]S protofibril strains that are transgenerationally transmitted to offspring during reproduction as a physiological phenomenon.
A[beta] Detection method type/aggregation state ELISA A[beta] oligomers Western blot A[beta] protofibril Immunoistochemistry A[beta] plaques Immunoistochemistry Amyloid deposition Pittsburgh compound in human brain B (PIB) PET A[beta] References type/aggregation state [8, 13-17, 48, 52] [12, 19, 32] * [18, 38, 40,41, 47] * (#) A[beta] oligomers [37] (#) [16, 17, 48] [44] * [46] * (#) [47] (#) A[beta] protofibril [19] * [12, 19, 44, 45] * A[beta] plaques [16, 17, 33, 48] [16, 37, 38, 40-42, 46, 47] * (#) Amyloid deposition [11,25, 29] * in human brain [19-22, 31] Amyloid-[beta] (A[beta]) refers to peptides derived from cleavage of the amyloid precursor protein (APP) by [beta]- and [gamma]-secretase.
Kelly, "The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation," Biochemistry, vol.
Polymerization propagates in this manner, forming a double-stranded protofibril in the process (see Figure 1(c)).
Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Ap antibody.