Eisai serves as the lead in the co-development of elenbecestat, a BACE inhibitor, and BAN2401, an anti-amyloid beta (Abeta) protofibril
antibody, and the companies plan to pursue marketing authorizations for the two compounds worldwide.
(Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") announced today that the investigational oral BACE (beta amyloid cleaving enzyme) inhibitor elenbecestat (development code: E2609) and the investigational anti-amyloid beta (A[beta]) protofibril
antibody BAN2401, which are currently being evaluated as treatments for early Alzheimer's disease (AD), have been selected by the ACTC as treatments to be evaluated in upcoming clinical studies targeting primary prevention (A3 Study) and secondary prevention (A45 Study) of AD.
Eisai (ESALY) announced that a global Phase III clinical study of BAN2401, an anti-amyloid beta protofibril
antibody, in patients with early Alzheimer's disease has been initiated.
BAN2401 is a selective anti-amyloid beta (A[sz]) protofibril
Hypothetically, stress information derived from both motor and nonmotor neurons might be integrated into diverse structures of [alpha]S protofibril
strains that are transgenerationally transmitted to offspring during reproduction as a physiological phenomenon.
A[beta] Detection method type/aggregation state ELISA A[beta] oligomers Western blot A[beta] protofibril
Immunoistochemistry A[beta] plaques Immunoistochemistry Amyloid deposition Pittsburgh compound in human brain B (PIB) PET A[beta] References type/aggregation state [8, 13-17, 48, 52] [12, 19, 32] * [18, 38, 40,41, 47] * (#) A[beta] oligomers  (#) [16, 17, 48]  *  * (#)  (#) A[beta] protofibril
 * [12, 19, 44, 45] * A[beta] plaques [16, 17, 33, 48] [16, 37, 38, 40-42, 46, 47] * (#) Amyloid deposition [11,25, 29] * in human brain [19-22, 31] Amyloid-[beta] (A[beta]) refers to peptides derived from cleavage of the amyloid precursor protein (APP) by [beta]- and [gamma]-secretase.
From conversion to aggregation: protofibril
formation of the prion protein.
Kelly, "The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril
formation," Biochemistry, vol.
Polymerization propagates in this manner, forming a double-stranded protofibril
in the process (see Figure 1(c)).
Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril
selective Ap antibody.