proto-oncogene


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Related to proto-oncogene: tumor suppressor gene

proto-oncogene

 [pro″to-ong´ko-jēn]
a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene.

proto-oncogene

/pro·to-on·co·gene/ (pro″to-ong´ko-jēn) a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene; most are believed to normally function in cell growth and differentiation.

proto-oncogene

(prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
n.
A normal gene that has the potential to become an oncogene.

proto-oncogene

Molecular medicine A normal gene with latent transforming potential, homologous to a retroviral oncogene Examples
c-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in normal growth, differentiation, and induction and/or maintenance of CA. See Abl, cyclin D1, RET/PTC.

proto-oncogene

Any gene capable of becoming a cancer-producing gene (an oncogene). Proto-oncogenes have important functions in the normal cell, but, by mutation or by the acquisition of genetic control elements from oncoviruses they can lose their normal regulatory functions and lead to uncontrolled multiplication.

proto-oncogene

a gene that normally functions to initiate or maintain cell division. However, it can be converted into an ONCOGENE by, for example, MUTATION.

proto-oncogene

a gene that is progenitor of an oncogene.
References in periodicals archive ?
Besides, some molecular and genetic alteration may contribute to malignant transformation, including aberrant somatic hypermutations of proto-oncogenes, DNA methylation of tumor suppressor genes, gains and losses of genetic material, as well as activation of the NF-?
Jhiang, "The RET proto-oncogene in human cancers," Oncogene, vol.
We also measured the mRNA levels of other proto-oncogenes JUN and MDM2, both of which after 72 hr exhibited significantly elevated expression at the tolerated [As.
Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study.
There are two mechanisms by which proto-oncogenes can be converted to cellular oncogenes: (5)
Las neoplasias malignas frecuentemente resultan por una serie de alteraciones geneticas que incluyen la activacion de proto-oncogenes y/o la inactivacion de los genes supresores tumorales (3).
Oral cancer progression and c-erb-B2/neu proto-oncogene expression.
Genetic testing confirmed that Brennan's DNA contains a mutation in the RET proto-oncogene on Chromosome 10.
As per scientists at The Feinstein Institute for Medical Research, the MET proto-oncogene is activated in a variety of tumor malignancies.
The previous case of adrenal medullary hyperplasia combined with myelolipoma was also a unilateral, sporadic case showing no abnormality in RET proto-oncogene (11).
Over-expression of the novel prostate-specific proto-oncogene, PCGEM1 is reputed to mediate aggressive prostate tumorigenesis, thus suggesting that it favors prostate cell division.