proto-oncogene


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to proto-oncogene: tumor suppressor gene

proto-oncogene

 [pro″to-ong´ko-jēn]
a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

proto-oncogene

(prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
n.
A normal gene that has the potential to become an oncogene.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

proto-oncogene

Molecular medicine A normal gene with latent transforming potential, homologous to a retroviral oncogene Examples
c-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in normal growth, differentiation, and induction and/or maintenance of CA. See Abl, cyclin D1, RET/PTC.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

proto-oncogene

Any gene capable of becoming a cancer-producing gene (an oncogene). Proto-oncogenes have important functions in the normal cell, but, by mutation or by the acquisition of genetic control elements from oncoviruses they can lose their normal regulatory functions and lead to uncontrolled multiplication.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

proto-oncogene

a gene that normally functions to initiate or maintain cell division. However, it can be converted into an ONCOGENE by, for example, MUTATION.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
* The report reviews Myc Proto-Oncogene Protein (Proto-Oncogene c-Myc or Class E Basic Helix-Loop-Helix Protein 39) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
This retrospective multicenter study aimed to evaluate the impact of free RET proto-oncogene testing of MTC patients.
Hiai, "Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains," Oncogene, vol.
At the onset of ischemia, there is an expression of the so-called group of early genes or proto-oncogenes (immediate early gene expression) [6].
There are two mechanisms by which proto-oncogenes can be converted to cellular oncogenes: (5)
A tumor in colon occurs mainly due to altered expression of two kinds of genes, proto-oncogenes and tumor suppressor gene.
Caillou et al., "High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation," Oncogene, vol.
Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases.
Cell apoptosis was evaluated and the expressions of JAK1, STAT3, non-metastasis23-1 (nm23-1), and apoptotic gene like B-cell lymphoma/leukemia-2 (bcl-2), B-cell lymphoma-extra large (bcl-xl), proto-oncogene proteins c myc (c-myc) and bcl-2- associated X (bax) were also examined.
Gluckman, "Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract," Annals of Otology, Rhinology and Laryngology, vol.
(11) Trastuzumab (Herceptin [R]) showed response rates of 21% to 40% in one trial." MET proto-oncogene has been shown to be over-expressed in 40% of lung cancers (11) and MET gene amplification has been shown to lead to EGFR inhibitor resistance.
The c-erbB2 proto-oncogene is a member of the Erb B family of transmembrane tyrosine kinase receptors.