proto-oncogene


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Related to proto-oncogene: tumor suppressor gene

proto-oncogene

 [pro″to-ong´ko-jēn]
a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene.

proto-oncogene

/pro·to-on·co·gene/ (pro″to-ong´ko-jēn) a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene; most are believed to normally function in cell growth and differentiation.

proto-oncogene

(prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
n.
A normal gene that has the potential to become an oncogene.

proto-oncogene

Molecular medicine A normal gene with latent transforming potential, homologous to a retroviral oncogene Examples
c-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in normal growth, differentiation, and induction and/or maintenance of CA. See Abl, cyclin D1, RET/PTC.

proto-oncogene

Any gene capable of becoming a cancer-producing gene (an oncogene). Proto-oncogenes have important functions in the normal cell, but, by mutation or by the acquisition of genetic control elements from oncoviruses they can lose their normal regulatory functions and lead to uncontrolled multiplication.

proto-oncogene

a gene that normally functions to initiate or maintain cell division. However, it can be converted into an ONCOGENE by, for example, MUTATION.

proto-oncogene

a gene that is progenitor of an oncogene.
References in periodicals archive ?
In this study we have shown that the RRM is capable of identifying the difference between oncogenes and proto-oncogenes and thus, identifying general "cancerous" feature within oncogene protein primary structures.
Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region.
Analysis of RET proto-oncogene mutation at codon 918 should be performed in all children born to parents with MEN 2B, as well as in children with ambiguous clinical features suggestive of MEN 2B.
Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease.
The discovery of molecular abnormalities of the RET proto-oncogene in MEN 2 and FMTC has significantly improved clinical management of these disorders.
This antibody has been used alone or in combination with established chemotherapeutic agents to treat breast cancer patients who overexpress the Her-2 proto-oncogene product.
The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung's disease.
The proto-oncogene Bcl-2 and its role in regulating apoptosis.
CD117 is a transmembrane tyrosine kinase receptor that is encoded by the proto-oncogene c-kit.
In research reported in the June CELL, they and colleagues found support for their hypothesis that the proto-oncogene normally controls the shape of a cell as it divides, while the viral oncogene probably disrupts the cell's shape.
The finding that the natural suppression of the Cyclin G1 gene is lost in cancer cells is not at all surprising to scientists at Epeius Biotechnologies, who first identified the human Cyclin G1 gene as a proto-oncogene in 1994, demonstrated its therapeutic potential in a comprehensive series of landmark studies (1995-2005), and designed the sophisticated dominant-negative "knockout" construct embodied in the powerful anti-cancer agent Rexin-G (see Gordon and Hall, Intl.