Pregnancy, the postpartum period and prothrombotic
defects: risk of venous thrombosis in the MEGA study.
DM is a prothrombotic
state with platelets being the central element of the atherothrombotic process due to their prothrombotic
and pro-inflammatory function.
CVT can also occur secondary to conditions or therapies which create a prothrombotic
state: inflammatory bowel diseases (Crohn's disease and ulcerative colitis), infections (sinusitis), trauma, nephrotic syndrome, liver cirrhosis, neoplasms, autoimmune diseases (systemic lupus erythematosus, granulomatosis with polyangiitis, Behcet's disease), sarcoidosis, anemia, pregnancy and puerperal period, high altitudes, use of drugs: oral contraceptives, erythropoietin, tamoxifen, corticosteroids, thalidomide, asparaginase .
There are a few hypotheses to explain the relationship between ECG abnormalities or myocardial injury and acute pancreatitis, which includes:  vagally mediated reflexes (cardiobiliary reflex) (2,3);  electrolyte abnormalities, such as hypokalemia, hypocalcaemia, hyponatraemia (2);  toxic effects of pancreatic proteolytic enzymes on myocardium--trypsin can change platelet adhesiveness, influence the coagulation system and lead to coronary thrombosis (5);  coronary artery spasm (3);  haemodynamic instability and /or systemic inflammatory response (SIRS) induces cardiac damage such as severe sepsis or septic shock (3); and  prothrombotic
(1,4) oxidative stress, (2,4) endothelial dysfunction, (2) and a hypercoagulable (2) and prothrombotic
statel have been associated with cardiometabolic disease.
In the presence of some prothrombotic
conditions, the risk of CVST increases when exposed to infection.
An increased D-dimer value in plasma is a reliable marker of a systemic prothrombotic
state, likely superior to alternative fibrinolytic markers, and its measurement might be helpful in predicting or preventing thrombotic events.4
However, after those high levels fall, patients taking diclofenac spend a substantial period of time with unopposed COX-2 inhibition, a state that is known to be prothrombotic
, and also associated with blood pressure elevation, atherogenesis, and worsening of heart failure.
gene mutations in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease.
(9) Higher doses of AAS are also associated with increased platelet aggregation, yielding a procoagulant state, through a dose-dependent prothrombotic
Patients with diabetes mellitus have a high risk of cardiovascular disease and the cardiovascular complications are the leading cause of morbidity and mortality associated with diabetes.1 Type-2 diabetes (T2D) creates a prothrombotic
state, leading to acute coronary syndromes by both endothelial damage and reducing antiaggregant factors, such as nitric oxide and prostacyclin and also increasing thrombotic substances such as fibrinogen, factor VII, and suppressing fibrinolysis by factors such as plasminogen activator inhibitors.2 Another important physiopathological process in diabetic patients is the glycosylation of low-density lipoprotein (LDL) particles.
Renal venous thrombosis in neonates: prothrombotic
risk factors and long-term follow-up.