prothrombin complex concentrate


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Related to prothrombin complex concentrate: cryoprecipitate, Prothrombin time, Activated prothrombin complex concentrate

concentrate

 [kon´sen-trāt]
1. to bring to a common center; to gather at one point.
2. to increase the strength by diminishing the bulk of, as of a liquid; to condense.
3. a drug or other preparation that has been strengthened by evaporation of its nonactive parts.
activated prothrombin complex concentrate (APCC) anti-inhibitor coagulant complex.
prothrombin complex concentrate (PCC) factor IX complex.

prothrombin complex concentrate

Hematology Any commercial product–eg, FEIBA–Factor VIII inhibitor by-passing activity that contain nonactivated factors IX, in addition to II, XI and X; PCCs may be used to ameliorate the intensity and duration of joint and soft tissue bleeding in hemophiliacs who produce factor VIII inhibitors; PCCs are 50% effective in staunching hemorrhage. See Prothrombin.
References in periodicals archive ?
Samama, Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.
Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers.
Le Bonniec et al., "Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model," Anesthesiology, vol.
Biopharmaceutical company China Biologic Products (NASDAQ:CBPO) disclosed on Friday the receipt of approval from the China Food and Drug Administration (the CFDA) for commercial manufacturing of human prothrombin complex concentrate (PCC) at its Shandong Taibang facility.
Reversal of dabigatran-induced bleeding with a prothrombin complex concentrate and fresh frozen plasma.
Treatment modalities for the actively bleeding patient who has been on VKA therapy include a recombinant VIIa product, fresh frozen plasma, and prothrombin complex concentrate. (3) The prothrombin complex concentrates contain factors, II, VII, IX, and X; optimal dosing of this product could be calculated using either measured or derived levels of these vitamin K-dependent factors.

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