prothrombin complex concentrate


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Related to prothrombin complex concentrate: cryoprecipitate, Prothrombin time, Activated prothrombin complex concentrate

concentrate

 [kon´sen-trāt]
1. to bring to a common center; to gather at one point.
2. to increase the strength by diminishing the bulk of, as of a liquid; to condense.
3. a drug or other preparation that has been strengthened by evaporation of its nonactive parts.
activated prothrombin complex concentrate (APCC) anti-inhibitor coagulant complex.
prothrombin complex concentrate (PCC) factor IX complex.

prothrombin complex concentrate (PCC)

prothrombin complex concentrate

Hematology Any commercial product–eg, FEIBA–Factor VIII inhibitor by-passing activity that contain nonactivated factors IX, in addition to II, XI and X; PCCs may be used to ameliorate the intensity and duration of joint and soft tissue bleeding in hemophiliacs who produce factor VIII inhibitors; PCCs are 50% effective in staunching hemorrhage. See Prothrombin.
References in periodicals archive ?
Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies.
Thrombogenicity of prothrombin complex concentrates.
Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.
Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal.
Reversal of Dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model.
Reversal of apixaban anticoagulation by 4Factor Prothrombin Complex Concentrates (PCC) in healthy subjects.
Prothrombin complex concentrates (PCCs) and plasma derived FVII (pdFVII) have higher potency compared to FFP and are suitable for surgery.
Ferreira J, DeLosSantos M The clinical use of prothrombin complex concentrates.
When FVII replacement is necessary in deficient patients, options include fresh-frozen plasma, prothrombin complex concentrates, and recombinant FVIIa.
Bayer HealthCare announced today results of an open-label, single-center, parallel-group Phase I study showing that three- and four-factor prothrombin complex concentrates (PCCs) can reverse the anticoagulant effect measured by coagulation assays in study participants treated with the oral anticoagulant XareltoA (rivaroxaban).

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