proteosome


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pro·te·o·some

(prō'tē-ō-sōm),
A cluster of genes that encode components of the cell cytosolic proteolytic complex, a set of proteins thought to be involved in cellular processing and transport of peptides in the formation of the major histocompatibility complex class I molecules.
[proteo- + G. sōma, body]

pro·te·o·some

(prō'tē-ō-sōm)
A cluster of genes that encode components of the cell cytosolic proteolytic complex, a set of proteins thought to be involved in cellular processing and transport of peptides in the formation of the major histocompatibility complex class I molecules.
[proteo- + G. sōma, body]

proteosome

(prōt′ē-ŏ-sōm″)
An intracellular enzyme that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteosomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin.
References in periodicals archive ?
falciparum cultures a 5.5-fold increase in a gene encoding an ubiquitin-specific protease and a 5.5-fold increase in a gene encoding a proteosome subunit a were observed [44].
She and her colleagues have discovered a way to take advantage of the proteosome defect.
The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.
Future prospective studies should focus on the use of adjuvant chemotherapy and/or novel therapeutic agents, i.e., proteosome inhibitors.
(6) New agents called proteosome inhibitors are very promising induction therapy agents, but they are currently still under investigation in various clinical trials as first-line therapy.
In the absence of functional Cosmc, core 1 [beta]3-Gal-T is degraded in the proteosome (53).
The primary aim of this work is to develop a sub-unit plague vaccine using a recombinant plague antigen, the FIV protein, formulated with the Proteosome technology.
ID Biomedical (Vancouver, Canada) received an official Notice of Allowance from the United States Patent and Trademark Office with respect to its patent application entitled, "Proteosome Influenza Vaccine".
Among the mRNAs of particular interest are homologues of sec6l (accession number BC019158), proteosome protein (BC003197), calmodulin-2 (NM_001743) and epsilon-container (AB042117), all proteins with potential function in membrane biogenesis.
Increased proteosome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
NF-[kappa]B inhibitors, including pyrrolidine dithiocarbamate [36], parthenolide [37], gliotoxin [38], and proteosome inhibitor [24], were reported to cause GSH depletion.
[p27.sup.Kip1] is regulated by p90 RSK and, once phosphorylated, is translocated to the cytosol, followed by ubiquitination and degradation by the proteosome, allowing progression to S-phase [38].