proteomics


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proteomics

(prō-tē-om'iks),
The identification and study of the proteins of a cell, tissue, or organism to determine their three-dimensional structure and to map their interactive networks to discover their function and the structure of drugs with the potential to interact in a therapeutic way with disease-associated proteins; goal is not only formulation of new drugs but also diagnostics and determining the presence of or absence of specific proteins associated with a disease or health.
See also: proteome, proteome image.

proteomics

(prō′tē-ō′mĭks)
n.
(used with a sing. verb) The analysis of the expression, localizations, functions, and interactions of the proteins expressed by the genetic material of an organism.

proteomics

The study of the proteome-the proteins expressed by the approximately 22,000 genes in the GENOME or by a cell. The form and quantity of the proteins produced by a cell cannot be fully predicted from DNA or RNA analysis alone. This is because of the controls and the many modifications that can occur in the stages between transcription and protein formation. Thus the totality of the genes can result in at least several hundred thousand different proteins. Proteomics includes the study of the factors that cause this multiplication. The discipline is being applied effectively to cancer studies.

proteomics

characterization of the PROTEOME by cataloguing and analysing the proteins. This involves:
  1. (a) identifying each protein in the proteome;
  2. (b) determining the sequence (see AMINO-ACID SEQUENCE of the proteins and constructing a database;
  3. (c) determining the amount of protein in different cell types and at different stages of development and
  4. (d) investigating the interactions between proteins.

proteomics

the comprehensive analysis of the identity, interactions and locations of proteins within a cell.
References in periodicals archive ?
Altogether the Congress aims to be an exemplary cross-discipline gathering in the proteomics life sciences for research presentation, discussion, learning, inspiration and encouragement with participants leaving with new research knowledge and ideas, and perhaps the beginnings of international collaborations and friendships.
Proteomics market is broadly classified on the basis of the following segments:
MRM Proteomics specializes in the highly multiplexed absolute quantitation of proteins in complex biological samples such as blood, cerebrospinal fluid and urine through MRM-MS using isotopically labeled internal standards.
Each chapter describes variations on the implementation of currently available proteomics technology from the perspective of the biomedical scientists trying to better understand human disease.
GeneProt's leading proteomics applications represent a great opportunity for us to utilize our existing platforms as well as develop technologies with the potential to further revolutionize the proteomics field," said Kevin Hrusovsky, Zymark president and CEO.
A particularly challenging area of study within proteomics is post-translational modification of proteins.
The second, and even more important, advantage is that proteomics may give us leads that we would simply never discover otherwise.
By revealing some of the unanticipated effects of a drug, activity-based proteomics could markedly reduce the cost of drug development.
We are excited to collaborate with MDS Proteomics, a leading proteomics company, in a large-scale effort to help change the nature of the drug development process," said R.
The Clinical Proteomics Programs established for this purpose will design panels of candidate proteins for disease areas, develop high throughput analytic methods, assess the predictive value of these proteomic measurements using biological specimens and clinical data from existing study populations, and establish procedures and standards for quality control.