proteomics

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Related to proteomic: Metabolomics

proteomics

(prō-tē-om'iks),
The identification and study of the proteins of a cell, tissue, or organism to determine their three-dimensional structure and to map their interactive networks to discover their function and the structure of drugs with the potential to interact in a therapeutic way with disease-associated proteins; goal is not only formulation of new drugs but also diagnostics and determining the presence of or absence of specific proteins associated with a disease or health.
See also: proteome, proteome image.

proteomics

(prō′tē-ō′mĭks)
n.
(used with a sing. verb) The analysis of the expression, localizations, functions, and interactions of the proteins expressed by the genetic material of an organism.

proteomics

The study of the proteome-the proteins expressed by the approximately 22,000 genes in the GENOME or by a cell. The form and quantity of the proteins produced by a cell cannot be fully predicted from DNA or RNA analysis alone. This is because of the controls and the many modifications that can occur in the stages between transcription and protein formation. Thus the totality of the genes can result in at least several hundred thousand different proteins. Proteomics includes the study of the factors that cause this multiplication. The discipline is being applied effectively to cancer studies.

proteomics

characterization of the PROTEOME by cataloguing and analysing the proteins. This involves:
  1. (a) identifying each protein in the proteome;
  2. (b) determining the sequence (see AMINO-ACID SEQUENCE of the proteins and constructing a database;
  3. (c) determining the amount of protein in different cell types and at different stages of development and
  4. (d) investigating the interactions between proteins.

proteomics

the comprehensive analysis of the identity, interactions and locations of proteins within a cell.
References in periodicals archive ?
Sample preparation is a tedious front-end process for virtually any MS analysis and presents a significant bottleneck in proteomics where differential analysis is used to compare protein expression and abundance between samples in increasingly greater volumes.
The markets for proteomic technologies are difficult to estimate as they are not distinct but overlap with those of genomics, gene expression, high throughput screening, drug discovery and molecular diagnostics.
The second challenge associated with proteomic analyses is the huge variation in protein expression levels.
We used this method for in situ SELDI-TOF MS proteomic analysis for differentiation of specific tissues in different mouse organs.
Henry Rodriguez, program director of the CPTI, told IBO, "The overall purpose of this program is to accelerate the implementation of proteomic analysis technology in identifying, validating and monitoring cancer-relevant proteins and peptides in clinical samples.
Genomic and proteomic data for the normal trajectory--compiled using samples from trauma and burn patients who recovered uneventfully--are now being analyzed.
The proteomic biomarker score distinguished severe preeclampsia from mild preeclampsia and controls with 85.
The company is dedicated to developing next generation proteomic research systems.
The enhanced proteomic panel was highlighted in a presentation at the 13th Annual International Future of Breast Cancer Meeting in Huntington Beach, California, on July 19 by Dr.
The subject of the public contract is to supply a file instrumentation allowing proteomic separation and analysis of chromatographic and electromigration techniques.
The first part explains basic principles and strategies for proteomic analysis of human body fluids, with chapters on sample preparation, multiplexed immunoassays, proteomic analysis of glycoproteins by mass spectrometry, and bioinformatics and experimental design for biomarker discovery.