The most important protein components of the myelin that target the immune system include myelin basic protein, myelin-associated glycoprotein, protein proteolipid
protein, and myelin oligodendrocyte glycoprotein.
found ADEM to be characterized by IgG autoantibodies targeting myelin basic protein, proteolipid
protein, myelin-associated oligodendrocyte basic glycoprotein and alpha-B-crystallin, whereas MS was characterized by IgM autoantibodies targeting myelin basic protein, proteolipid
protein, myelin-associated oligodendrocyte basic glycoprotein, and oligodendrocyte specific protein.
It is reported that a numerous neuroendocrine self-antigens are expressed by the thymic epithelium which is controlled by the autoimmune regulator (AIRE) gene/protein. According to a review, numerous gens are expressed in the thymus, including circulatory, central nervous, digestive, and eyes. Myelin basic protein (MBP) is the second most abundant protein after proteolipid
protein (PLP) in CNS.
PLP1 is further translated into the proteolipid
protein 1 (PLP1), a 276 aminoacid peptide, or the isoform called DM20, which loses 35 residues inside its intracellular loop.
This dependency has been demonstrated in mice deficient in the myelin-specific proteolipid
Pascual, "Bystander-mediated stimulation of proteolipid
protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-[beta]," Journal of Neuroimmunology, vol.
protein (PLP) peptide (p)139-151, corresponding to the mouse sequence (HSLGKWLGHPDKF) was synthesized on a peptide synthesizer and purified by HPLC.
SSC, Sus scrofa chromosome, AR, androgen receptor, PGK1, phosphoglycerate kinase 1, PLP1, proteolipid
protein 1, tBg, thyroxine-binding globulin, CAPN6, calpain 6.
The persistency of these conditions would bring to supercomplex disaggregation and alteration of the mitochondrial proteolipid
The most common cause of PMD is a mutation of the Proteolipid
protein (PLP) gene producing a structural protein involved in the construction of central nervous system myelin [3-6].
(1994) Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid
Pelizaeus Merzbacher's Disease (PMD) also called leukodystrophy hypomyelinating 1 (HDL1) is an inherited allelic leukodystrophy caused by mutations of the proteolipid
protein 1 gene (PLP1).