OUMS-27 cell line secretes cartilage-specific proteoglycans
, and type-2 and -9 collagens.
Small leucine-rich proteoglycans
(SLRPs) are ECM proteoglycans
required for collagen fibrillogenesis.
The Safranin O staining showed a significantly different proteoglycan
profile between the CON group and the injury groups.
5 and 1%) solution of proteoglycan
extracted from nasal cartilage of Oncorhynus keta (Salmon) having property like epidermal growth factor was used as a positive control.
Aside from water, which comprises 70-80% of human cartilage, collagen and proteoglycans
are its major components, each assuming 10-20% of the avascular glossy covering of the underlying subchondral bone, followed by the chondrocytes, which produce and maintain the cartilage ECM and comprise 1-5% of it.
In osteoarthritis, early proteoglycan
loss leads to expansion of the residual proteoglycans
and increased cartilage water content, which may appear as increased cartilage thickness on MRI.
are an important component in the extracellular matrix, and they form large complexes by linking with other proteoglycans
and molecules such as hyaluronic acid (hyaluronan) and collagen.
Glycomics is the analysis of the structure and functions of glycans or oligosaccharides (chains of sugars) attached to biomolecules and includes the analysis of glycoproteins, proteoglycans
, glycolipids, peptidoglycans, and lipopolysacchrarides.
Syndecan-2 is but one member of the syndecan family of heparan sulfate proteoglycans
Furthermore, studies have demonstrated that small, dense LDL particles penetrate more easily into the arterial intima (1), exhibit increasing binding to arterial wall proteoglycans
(2), and are more prone to oxidative stress (3).
The extracellular matrix (ECM) is composed of a great variety of molecules and includes collagen family, elastic fibers, glycosoaminoglycans and proteoglycans
, and adhesive glycoproteins.
They will develop insight into the mechanisms of post-mortem meat degradation; identify and characterize proteins and proteoglycans
that influence product quality; and characterize and quantify microstructure and important components both in the raw material and end product.