proteoglycan aggregate

proteoglycan aggregate

a large aggregation of proteoglycans noncovalently bound to a long molecule of hyaluronic acid; involved in cross-linking the collagen fibrils of cartilage matrix.

pro·te·o·gly·can ag·gre·gate

(prō'tē-ō-glī'kan ag'rĕ-găt)
A large aggregation of proteoglycans noncovalently bound to a long molecule of hyaluronic acid; involved in cross-linking the collagen fibrils of cartilage matrix.
References in periodicals archive ?
A sampling of topics: force-mediated dissociation of proteoglycan aggregate in articular cartilage, chondrocyte gene expression under applied surface motion, subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis, increased apoptosis in rat osteoarthritic cartilage corresponds to degenerative chondral lesions and concomitant expression of caspase-3, mesenchymal progenitor cells in adult human articular cartilage, acoustic properties of articular cartilage under mechanical stress, and bi- zonal cartilaginous tissues engineered in a rotary cell culture system.
10],[11] Proteoglycan aggregates in adult human nucleus pulposus are mainly distributed within the extracellular matrix, while those of the annulus fibrosis are mainly distributed between collagen fibers.
Papain destroys the core protein collagen chain and proteoglycan aggregates leading to loss of cartilage integrity (Murat et al.
Degradation and loss of large chondroitin sulfate proteoglycan aggregates has been observed in atherogenesis (20, 25) and in OA (26), and proteoglycan biosynthesis and accumulation of unique proteoglycan epitopes are markedly altered in both diseases (2, 23, 24).
It seems possible that these filaments are part of the hyaluronic backbone of proteoglycan aggregates.