A sampling of topics: force-mediated dissociation of proteoglycan aggregate
in articular cartilage, chondrocyte gene expression under applied surface motion, subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis, increased apoptosis in rat osteoarthritic cartilage corresponds to degenerative chondral lesions and concomitant expression of caspase-3, mesenchymal progenitor cells in adult human articular cartilage, acoustic properties of articular cartilage under mechanical stress, and bi- zonal cartilaginous tissues engineered in a rotary cell culture system.
10], Proteoglycan aggregates
in adult human nucleus pulposus are mainly distributed within the extracellular matrix, while those of the annulus fibrosis are mainly distributed between collagen fibers.
Papain destroys the core protein collagen chain and proteoglycan aggregates
leading to loss of cartilage integrity (Murat et al.
Degradation and loss of large chondroitin sulfate proteoglycan aggregates
has been observed in atherogenesis (20, 25) and in OA (26), and proteoglycan biosynthesis and accumulation of unique proteoglycan epitopes are markedly altered in both diseases (2, 23, 24).
It seems possible that these filaments are part of the hyaluronic backbone of proteoglycan aggregates