proteoglycan


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proteoglycan

 [pro″te-o-gli´kan]
any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the intercellular ground substance of connective tissue. Called also mucopolysaccharide.

pro·te·o·gly·can

(prō'tē-ō-glī'kan),
A glycoaminoglycans (mucopolysaccharides) bound to protein chains in covalent complexes; occur in the extracellular matrix of connective tissue.

proteoglycan

/pro·teo·gly·can/ (pro″te-o-gli´kan) any of a group of polysaccharide-protein conjugates present in connective tissue and cartilage, consisting of a polypeptide backbone to which many glycosaminoglycan chains are covalently linked; they form the ground substance in the extracellular matrix of connective tissue and also have lubricant and support functions.

proteoglycan

(prō′ē-ō-glī′kən)
n.
Any of various glycoproteins that have glycosaminoglycan chains attached by covalent bonds to the protein, usually found in the extracellular matrix of connective tissue.

pro·te·o·gly·can

(prō'tē-ō-glī'kan)
Glycoaminoglycans bound to protein chains in covalent complexes; found in extracellular matrix of connective tissue.

proteoglycan

any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the intercellular ground substance of connective tissue. Called also mucopolysaccharide.
References in periodicals archive ?
In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4.
Extracellular mammalian polysaccharides: glycosamino-glycans and proteoglycans.
Poole, "Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis: evidence for molecular heterogeneity and extensive molecular changes in disease," Journal of Clinical Investigation, vol.
Commercial bovine proteoglycan is highly arthritogenic and can be used as an alternative antigen source for PGIA model," BioMed Research International, vol.
The proteoglycans in ECM serve as a bridge between cells and matrix, and contributes to construction of ECM by affecting collagens.
In particular the presence of aggrecan confers tremendous water-binding capacity to the NP with vital ECM-maintenance conferred by a number of other smaller single leucine-rich proteoglycans or "SLRPs".
ECM consists of several distinct components (Figure 1) which can be divided into three groups: i) structural proteins, such as collagen and elastin, ii) specialized adhesion proteins, such as fibronectin, fibrilin, and laminin, iii) glycosaminoglycans (GAG) and proteoglycans (PG).
As no other interruption was performed in the injury groups, the changes in histology, the proteoglycan profile, cell density, and FZT were caused by the puncture; these changes persisted at 8 weeks post injury.
In comparison of A1, B1 and C1 all discs in group A and most of the disc (eight) in group C showed normal lamellar and wavy pattern of collagen / proteoglycan with abundant distribution of fibrocytes and chondrocytes in normal scattered manner as shown in Figure 1.
It was possible to compare all cases of each proteoglycan studied, because all the specimens were treated equally.
Heparan sulphate (HS) is a proteoglycan synthesized in the endothelial cells and found in the extracellular part of the plasma membrane.
5 and 1%) solution of proteoglycan extracted from nasal cartilage of Oncorhynus keta (Salmon) having property like epidermal growth factor was used as a positive control.