proteoglycan


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proteoglycan

 [pro″te-o-gli´kan]
any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the intercellular ground substance of connective tissue. Called also mucopolysaccharide.

pro·te·o·gly·can

(prō'tē-ō-glī'kan),
A glycoaminoglycans (mucopolysaccharides) bound to protein chains in covalent complexes; occur in the extracellular matrix of connective tissue.

proteoglycan

(prō′ē-ō-glī′kən)
n.
Any of various glycoproteins that have glycosaminoglycan chains attached by covalent bonds to the protein, usually found in the extracellular matrix of connective tissue.

pro·te·o·gly·can

(prō'tē-ō-glī'kan)
Glycoaminoglycans bound to protein chains in covalent complexes; found in extracellular matrix of connective tissue.
References in periodicals archive ?
(2000) Synthesis of proteoglycans and collagen in primary cultures of mantle cells from the nacreous mollusk, Haliotis tuberculata: a new model for study of molluscan extracellular matrix.
Hascall, "Assembly of newly synthesized proteoglycan and link protein into aggregates in cultures of chondrosarcoma chondrocytes," Journal of Biological Chemistry, vol.
Wight, "Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells," The Journal of Biological Chemistry, vol.
The intervertebral disc cells can degrade proteoglycan and glycoprotein in matrix, such as fibronectin, laminin, and gelatin and can also degrade elastin and types II, III, IV, V, and VI collagen [30].
Chakravarti, "The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis," Journal of Internal Medicine, vol.
Miao, "Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex," Matrix Biology, vol.
Different properties of glioma cell proliferation and clearance are associated with distinct glioma ECM components; in 20-day gliomas, ECM components such as chondroitin sulfate proteoglycan, tenascin C, and type IV collagen were elevated, in comparison with values obtained for the 10-day glioma group.
Notably that the chondroitin sulfate proteoglycans (CSPGs) such as versican accumulate in tumor stroma and play a key role in tumor growth and invasion.
Endocan is a soluble proteoglycan that is detected in the blood and is expressed by endothelial cells of the vasculature, lung, and kidney [16,17].
B3GAT3 transcribes the 335-amino-acid glucuronyltransferase I (GlcAT-I) protein which catalyses the final step in proteoglycan biosynthesis through the addition of a xylosegalactose-galactose-glucuronic acid tetrasaccharide linkage molecule [16].
The sections were then stained with hematoxylin and eosin for general histological assessment, where the grading of hematoxylin and eosin staining was determined according to Mankin's scoring system [8], or with Masson staining for assessment of cartilage collagen and toluidine blue for assessment of cartilage proteoglycan. For the immunohistochemical analysis of anti-rat primary polyclonal antibodies, slides were incubated with types I and II collagen antibodies (Boster Biological Engineering Co., Ltd., Wuhan, China) overnight at 4[degrees]C in a wet room and then with the secondary antibody (Boster Biological Engineering Co., Ltd., Wuhan, China).
They found decrease in collagen expression at both protein and mRNA level as well as impaired proteoglycan synthesis, whereas overall protein synthesis was slightly affected.