protein-tyrosine kinases


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protein-tyrosine kinases

A large class of enzymes that catalyse the transfer of phosphate from ATP to tyrosine residues in polypeptides. Their products regulate cell proliferation, survival, differentiation, function and motility. These enzymes are regarded as excellent targets for cancer chemotherapy. Drugs such as imatinib mesylate inhibit these enzymes.
References in periodicals archive ?
Characterization and phylogenetic analysis of a cDNA encoding the Fes/FER related, non-receptor protein-tyrosine kinase in the marine sponge Sycon raphanus.
The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tyrosine kinases.

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