protein-bound

protein-bound

Linked to polypeptides; not freely circulating in the plasma. Drugs or toxins that are heavily protein-bound have less impact on body receptors and metabolic functions than those that circulate in a free (unbound) state.

protein-bound

said of a chemical bonding of calcium, iodine, iron, copper and other electrolyte ions in the blood to plasma proteins. The bound electrolyte is not immediately available biologically nor is it as vulnerable to sudden loss.

protein-bound-bound iodine (PBI) test
determination of thyroid function by measuring the amount of iodine contained in compounds bound to plasma proteins. It has been largely replaced by radioimmunoassay for the thyroid hormones thyroxine (T4) and tri-iodothyronine (T3).
References in periodicals archive ?
As part of the settlement, the parties will file a Consent Judgment with the United States District Court for the District of New Jersey that enjoins Actavis from marketing generic paclitaxel protein-bound particles for injectable suspension before expiration of the patents-in-suit, except as provided for in the settlement.
M2 EQUITYBITES-March 8, 2016-Celgene announces US FDA Paragraph IV Notice Letter for ANDA for ABRAXANE (paclitaxel protein-bound particles for injectable suspension) (albumin bound) 100 mg/vial
M2 PHARMA-March 8, 2016-Celgene announces US FDA Paragraph IV Notice Letter for ANDA for ABRAXANE (paclitaxel protein-bound particles for injectable suspension) (albumin bound) 100 mg/vial
2), (3) PP affects both protein-bound and free drug concentrations.
Advocacy of the more efficient dialysis modalities with the high flux (HF) and super-flux (SF) membranes stresses the importance to study the behaviour of non-protein-bound and protein-bound uremic toxins in respect to their removal characteristics with different membranes [5].
DESIGN: Review of three clinical studies beginning in 1975: an uncontrolled study with sodium iodide and protein-bound iodide; a prospective, control, crossover study from iodide to molecular iodine; and a prospective, control, double-blind study with molecular iodine.
Protein-bound lipid is not as damaging to foam as free lipid, although scientists do not know the impact effect of protein binding on lipid oxidation.
A paclitaxel protein-bound particles for injectable suspension indicated for the treatment of breast cancer, ABRAXANE was approved by the US Food and Drug Administration in January 2005 and is currently marketed by Abraxis Oncology in North America.
Typically, drugs that are highly protein-bound are not widely distributed--that is, they do not reach many organs but stay in the bloodstream because they are unable to cross biological membranes.
The transaction adds ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) to the company's existing portfolio of leading cancer products and offers another significant scientific platform that may drive future development.
The firm stated that the product leverages the same technology as the nab platform that is behind the success of ABRAXANE (paclitaxel protein-bound particles for injectable suspension).

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