protein splicing


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protein splicing

a post-translational process in which an internal segment, termed the intervening protein sequence (IVPS), of some PROTEINS is removed, before folding into the final configuration. A new PEPTIDE BOND is formed between the sequences that originally flanked the IVPS. It is an AUTOCATALYTIC reaction.
References in periodicals archive ?
Myotonic dystrophy type 1 involves a type of RNA defect known as a "triplet repeat," a series of three nucleotides repeated more times than normal in an individual's genetic code, resulting in a number of protein splicing abnormalities.
various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins.
Since 1990, biologists have observed this bizarre phenomenon, called protein splicing, in about 100 proteins in some 30 single-celled organisms throughout nature.
Since the researchers reported this proof that protein splicing happens, investigators have worked to describe the steps by which an intein cleaves the chemical bonds that hold it within the precursor protein and then seamlessly joins the protein fragments from which it has escaped.
What we still have to discover is how protein splicing is controlled.
4 Split Luciferase Systems for Detecting Protein-Protein Interactions in Mammalian Cells Based on Protein Splicing and Protein Complementation (Yoshio Umezawa).