Manfredi, "The tumor suppressor protein p53
requires a cofactor to activate transcriptionally the human BAX promoter," Journal of Biological Chemistry, vol.
Objective: To investigate B-cell-lymphoma-2 and tumour protein p53
expression in hepatic tissues of human cases of Chronic Hepatitis C.
Following DNA damage, the tumor suppressor protein p53
has a crucial influence on whether cells will survive or die by either stimulating DNA repair or initiating apoptosis if the DNA damage has exceeded a certain threshold.
Breast cancer genome analyses have shown that there are a few tumour suppressor genes that are frequently mutated such as breast cancer 1, early onset (BRCA1) and tumour protein p53
(TP53) genes (2).
Aileron Therapeutics will use the the funds to proceed with the clinical trials of ALRN-6924, a potent and specific re-activator of tumour suppressor protein p53
, as well as to advance ongoing translational research, according to the press release.
Chi-square test was used (Table 5) to compare frequency of Protein P53
expression in Normal, Dysplastic and Malignant cases.
For example, TP53 (tumor protein p53
, also known as p53)  signatures are present in 25% of tubal epithelium samples in healthy controls (3).
expression was seen in 60% of oral epithelial dysplastic lesions and 67% of oral squamous cell carcinomas.
Gene p53 mutations, protein p53
, and anti-p53 antibodies as biomarkers of cancer process.
Certain mutations of the protein p53
, a tumor suppressor, can cause the protein to fold in an abnormal manner that causes proteins to cluster, which disrupts the protective function of normal p53 and other related proteins.
In particular, several proteins involved in DNA damage signaling and repair, replicative enzymes such as DNA and RNA polymerases and transcription factors such as tumour protein p53
(17), require zinc for proper functions (18-20).
Washington, Nov 25 (ANI): Cancer biologists have revealed that restoring the gene for cancer protein p53
could slow the spread of advanced lung tumours, but doesn't help early-stage cancers.