protein kinases


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Related to protein kinases: Phosphatases

pro·tein ki·nas·es

a class of enzymes that phosphorylates other proteins; many of these kinases are responsive to other effectors (for example, cAMP, cGMP, insulin, epidermal growth factor, calcium, and calmodulin, calcium, and phospholipids).
References in periodicals archive ?
Schulman, "Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II," Biochemical Journal, vol.
Van den Berghe, "Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase," The FASEB Journal, vol.
TC10 has homology sequence with Cdc42 and Rac and binds to effectors having a Cdc42-/Rac-interactive binding domain, such as p21-activated protein kinase, the neural Wiscott-Aldrich syndrome protein (N-WASP) [85], and also proteins without these domains, for instance, Exo70 [86], PIST [87], and CIP4 [88].
Moreover, Figure SI also displays the ROC curves of the three most pleiotropic protein kinases (i.e., PKCA, PKACA, and CK2A1), from which we can get a consistent conclusion.
The membranal PIP3, a signaling molecule, recruits and activates proteins that contain the pleckstrin homology (PH) domain such as the phosphoinositide-dependent protein kinase (PDK) and protein kinase B (Akt) serine/threonine kinases and the activation of PDK and Akt successively promotes the activation and transcription of their target genes (GSK3, FOXO, BAD, mTOR1, and p53) [89-92].
Cohen, "Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases," FEBS Letters, vol.
Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem J.
Mitogen-activated protein kinase phosphatases (MKPs) can recognize MAPKs by recognizing the TXY amino acid motif and consequently dephosphorylate and deactivate them.
PKC and [Ca.sup.2+]/calmodulin-dependent protein kinase were not activated with glycolipids, indicating that the activation of cAMP-kinase by glycolipids was fairly specific.

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