protein kinases


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Related to protein kinases: Phosphatases

pro·tein ki·nas·es

a class of enzymes that phosphorylates other proteins; many of these kinases are responsive to other effectors (for example, cAMP, cGMP, insulin, epidermal growth factor, calcium, and calmodulin, calcium, and phospholipids).
References in periodicals archive ?
The human genome encodes at least 538 protein kinases that regulate each other and another 21,500 diverse proteins to coordinate all cellular operations.
2]-terminal kinase (JNK), are a family of serine/threonine protein kinases that transmit extracellular signals into the nucleus (Schaeffer and Weber 1999).
One mutation turns out to be in a gene that codes for a protein kinase, an enzyme that adds a phosphate to a protein, which then becomes the next signal in this chemical cascade.
Arrien is seeking collaborations with companies for a number of programs for which it expects to file 2 INDs between Q4 2011-12 related to protein kinase mediated Parkinson's, Cancer and other disease indications.
The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells.
Table 23: Innovations in Protein Kinase Therapies - GlaxoSmithKline Protein Kinases Pipeline Status, 2010 62
Over the last year, Kinexus and their collaborators in the Mathematics of Information Technology and Complex Systems (MITACS) groups at the University of British Columbia and Simon Fraser University have worked to identify the specific parts of different protein kinases that are critical for recognition by each of 550 different compounds that have been experimentally shown to inhibit one or more kinases.
They found that when these neurons also expressed Preso1, the mGluRs bound Homer more efficiently, suggesting that Preso1 might somehow increase modification by protein kinases.
Signaling pathways involved in the assembly, disassembly, and maintenance of TJ are controlled by a number of signaling molecules, such as protein kinase C, mitogen-activated protein kinases, myosin light chain kinase, and Rho GTPases.
Protein kinases are a large group of related enzymes that activate many kinds of proteins, thus mediating signal transduction in cell growth and differentiation.
Since their identification in the 1980s as having an important role in oncogenesis and tumor progression, protein kinases have received increasing attention as targets for anticancer drugs.

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