protein kinase


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Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

/pro·tein ki·nase/ (pro´tēn ki´nās) an enzyme that catalyzes the phosphorylation of serine, threonine, or tyrosine groups in enzymes or other proteins, using ATP as a phosphate donor.

protein kinase

n.
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.

protein kinase (PKA)

a protein that catalyzes the transfer of a phosphate group from adenosine triphosphate to produce a phosphoprotein.

protein kinase

This name was officially retired in 2005; however, although the term is nonspecific, it is still in common use. It is now formally divided into:
• EC 2.7.11.1, non-specific serine/threonine protein kinase;
• EC 2.7.11.8, Fas-activated serine/threonine kinase;
• EC 2.7.11.9, Goodpasture antigen-binding protein kinase;
• EC 2.7.11.10, IκB kinase;
• EC 2.7.11.11, cAMP-dependent protein kinase;
• EC 2.7.11.12, cGMP-dependent protein kinase;
• EC 2.7.1.13, protein kinase C;
• EC 2.7.11.21, polo kinase;
• EC 2.7.11.22, cyclin-dependent kinase;
• EC 2.7.11.24, mitogen-activated protein kinase;
• EC 2.7.11.25, mitogen-activated protein kinase kinase kinase;
• EC 2.7.11.30, receptor protein serine/threonine kinase; and
• EC 2.7.12.1, dual-specificity kinase.

protein kinase

an ENZYME that catalyses the transfer of a phosphate group from ATP to an AMINO ACID in a PROTEIN. In this way, the activity of enzymes can be decreased or increased. By thus altering proteins, kinases are thought to be important in mediating various processes in the CELL.
References in periodicals archive ?
Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinese C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats.
Kinexus is poised to become a major proteomics and bioinformatics player with its focus on protein kinases and other cell signalling proteins for diagnostic and therapeutic applications.
The catalytic subunit of protein kinase A was expressed using plasmid pRSET B based on the T7 promoter expression system (from Invitrogen).
PKN3 is a protein kinase C-related molecule, involved in the PI3-kinase pathway that is believed to play an important role in the growth of cancer cells, as well as metastasis formation.
Significantly down-regulated genes in our study included the MAPK group and DNA-dependent protein kinase group, which are kinases involved in cellular growth and apoptosis.
The researchers suggest that protein kinase C signaling is a target of PBDE-99 toxicity in the developing mouse brain.
com/research/q4vghk/triple_analysis_l) has announced the addition of the "Triple Analysis: Lymphoma, Cancer Vaccines and Protein Kinase Inhibitors" report to their offering.
M2 PHARMA-December 7, 2011-EPO upholds Silence Therapeutics' patent on protein kinase N beta(C)2011 M2 COMMUNICATIONS
They have discovered that activation mechanism of the RAF protein kinase which, when mutated, is responsible for more than 25 per cent of cancers.
Polyphenols up- or down-regulated activity of a number of key enzymes, including mitogen-activated protein kinases and protein kinase C, and increased or decreased protein/mRNA levels, including that of cyclins, oncogenes, and tumor suppressor genes.

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