protein folding


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protein folding

The shaping of a protein into its unique three-dimensional conformation from the linked amino acids of which it is composed.

protein folding

The process by which proteins acquire their normal, energetically-favourable, three-dimensional form. The folding has long been believed to be specified by the amino acid sequence, but recent research suggests that proteins may fold into abnormal shapes by mechanisms not yet determined. Abnormal folding results in loss of normal protein function but also in proteolytic degradation and the accumulation of fragments that form insoluble plaques in the various organs including the brain and the liver. This is believed to be the way in which the characteristic plaques and fibrillary tangles of ALZHEIMER'S DISEASE occur.
References in periodicals archive ?
Typical experiments were performed with 6.4 ms-6 s folding times and 20 ms labeling duration in high pH (pH 10.1) with a deuterated buffer after the initiation of protein folding. (40) The protein is first unfolded in the presence of either 6 M urea or low pH solution (pH 2.2), (39) and after the dilution of the denaturant or acidic solution, the protein folding is initiated.
The protein folding problem is arguably the hottest topic today in biochemical and biophysics research.
One possibility is that protein folding involves the violation of natural law by a supernatural agent.
In this section the protein folding problem is briefly described and the next methods are explained: SA, MQA, and CMQA.
A new electron diffraction technique allows the bending and shifting of these ions--a process that takes mere picoseconds--to be directly imaged for the first time, The system could unlock the secrets of more complex motions, like protein folding.
The protein folding problem is the search for this native state for a given sequence of amino acid residues.
Stanford UniversityCOs distributed computing programme Folding@home has become a major force in researching cures to life-threatening diseases such as cancer, cystic fibrosis, and ParkinsonCOs disease by combining the computing horsepower of millions of processors to simulate protein folding.
Imagine using your PC to simulate protein folding to help find a cure for debilitating diseases.
Computer simulations help, but because a single protein folding requires just 10 [micro]sec, a model requires years or even decades to complete.
Also published quarterly, "Prion" is an international journal that focuses on protein folding and mis-folding, protein assembly disorders, and protein-based and structural inheritance.
William Skach, who studies protein folding at Oregon Health and Science University in Portland, notes that differences in proteins that have identical amino acids "could be very widespread and not appreciated at all right now."
Protein folding is influenced by the change in enthalpy ([DELTA]H) of the structure.