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a vitamin K-dependent glycoprotein that inhibits coagulation by enzymatic cleavage of the activated forms of factors V and VIII, and thus interferes with the regulation of intravascular clot formation; a deficiency of protein C leads to impaired regulation of blood coagulation. There is an autosomal dominant deficiency [MIM*176860] that, like antithrombin III deficiency and plasminogen deficiency, is associated with an increased risk of severe or premature thrombosis.
Farlex Partner Medical Dictionary © Farlex 2012
PROCA gene on chromosome 2q13-q14 that encodes a vitamin K-dependent plasma glycoprotein, which is cleaved to its activated form by the thrombin-thrombomodulin complex. Once activated, it degrades activated coagulation factors V and VIII.
PROC mutations are linked to thrombophilia due to protein C deficiency, neonatal purpura fulminans and recurrent venous thrombosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Vitamin K-dependent glycoprotein that inhibits coagulation by enzymatic cleavage of the activated forms of factors V and VIII, and thus interferes with the regulation of intravascular clot formation.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
protein CA plasma protein that inhibits clotting.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005