protein C


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pro·tein C

a vitamin K-dependent glycoprotein that inhibits coagulation by enzymatic cleavage of the activated forms of factors V and VIII, and thus interferes with the regulation of intravascular clot formation; a deficiency of protein C leads to impaired regulation of blood coagulation. There is an autosomal dominant deficiency [MIM*176860] that, like antithrombin III deficiency and plasminogen deficiency, is associated with an increased risk of severe or premature thrombosis.

PROC

A gene on chromosome 2q13-q14 that encodes a vitamin K-dependent plasma glycoprotein, which is cleaved to its activated form by the thrombin-thrombomodulin complex. Once activated, it degrades activated coagulation factors V and VIII.

Molecular pathology
PROC mutations are linked to thrombophilia due to protein C deficiency, neonatal purpura fulminans and recurrent venous thrombosis.

pro·tein C

(prōtēn)
Vitamin K-dependent glycoprotein that inhibits coagulation by enzymatic cleavage of the activated forms of factors V and VIII, and thus interferes with the regulation of intravascular clot formation.

protein C

A plasma protein that inhibits clotting.