Huang, "Crystallization of antimicrobial pores in membranes: magainin and protegrin
," Biophysical Journal, vol.
The duo studied the amino acid sequences and three-dimensional structures of over 500 antimicrobial peptides, and found the [gamma]-core structure in molecules as diverse as pea defensins, fruit fly drosomycin, pig protegrin
, and human hepcidin.
6,025,326, entitled "Compositions and Methods for the Prevention and Treatment of Oral Mucositis." This patent addresses the use of antimicrobial peptides, including Protegrin IB-367, for the treatment of oral mucositis, a severe and painful condition occurring in cancer patients receiving cancer therapies.
"Along with the prior patent on the Protegrin IB-367 composition of matter, this latest patent provides IntraBiotics with very strong patent protection for its antimicrobial approach to potentially preventing a serious and debilitating side effect of cancer treatment."
Certain AMPs such as pexigan an MSI-78, citropin 1.1, protegrin
1, synthetic lipopeptide, and N-[alpha]-palmitoyl-L-lysine-L-lysine amide (Pal-Lys-Lys-N[H.sub.2]) showed cytotoxic activity against U937 histiocytic cell line.
has reported in two posters presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) results of studies on the company's novel antimicrobial peptide compound, Protegrin IB-367.
To date, Protegrins have not been shown to display a resistance problem in controlled laboratory experiments.
Approximately a dozen cathelicidins such as protegrins (PG1-5) and 29 porcine [beta]-defensins (PBDs) have been reported in pigs [6, 7].
Because several other porcine HDP genes such as PBD2, epididymis protein 2 splicing variant C (EP2C), and protegrins are also readily induced by fatty acids , cloning of those HDP gene promoters into the pGL4.21 luciferase reporter vector is expected to yield a similar outcome to the current HTS assay.
Among AMPs, the most studied ones are colistin, melittin, indolicidin, nisin, CAMA, defensins, protegrins
, magainins, etc.
Membranolytic selectivity of cystine-stabilized cyclic protegrins
. Eur J Biochem 2000; 267: 3289-3300.