protective antigen


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protective antigen

The protein made by Bacillus anthracis, which binds to cell membranes and allows the lethal components of anthrax toxin to enter and kill cells.
See also: antigen
References in periodicals archive ?
Vaccination against anthrax with attenuated recombinant strains of Bacillus anthracis that produce protective antigen. Infect Immun., 1999; 67(2): 562-7.
Vaccination with BM86, subolesin and akirin protective antigens for the control of tick infestations in white tailed deer and red deer.
Emergent is also working on a next generation of vaccines that stimulate the immune response to protective antigen as well as a monoclonal antibody treatment.
A vaccine consisting of protective antigen of an avirulent, noncapsulated strain of B.
Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop.
Rapid enzyme-linked immunosorbent assays for protective antigen and polymerase chain reaction testing are available only at national reference labs and on emergency response buses set up to rush specialized teams to bioterrorist attack sites.
But scientists at Porton Down, who tested blood samples from five Scots victims, said two tested positive for the main anthrax toxin, Protective Antigen.
Anthrax protective antigen administered by DNA vaccination to distinct subcellular locations potentiates humoral and cellular immune responses.
PHE will reportedly develop and evaluate a novel solid-dose formulation of a number of its proprietary vaccine candidates including Anthrax recombinant Protective Antigen (rPA) and Crimean-Congo Haemorrhagic Fever (CCHF) for delivery using Enesi Pharma's ImplaVax needle-free technology.
Enolase has been analyzed as a vaccine in several parasites and bacteria, demonstrating that it may be an important immunogenic protein and a protective antigen [20-22, 53-55].
The neutrophi-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The investigational antibody is designed to target a protein component known as the anthrax protective antigen (PA) of the lethal toxin complex produced by the bacterium.

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