protease


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Related to protease: Protease inhibitors

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

pro·te·ase

(prō'tē-āz),
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (break) polypeptide chains.

protease

(prō′tē-ās′, -āz′)
n.
Any of various enzymes, including the endopeptidases and exopeptidases, that catalyze the hydrolytic breakdown of proteins. Also called peptidase.

pro·te·ase

(prō'tē-ās)
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (i.e., break) polypeptide chains.

protease

One of a range of protein-splitting enzymes. One focus of current interest in proteases is in their role in breaking down tissue barriers in the spread of cancer. High concentrations of the activator of one of these proteases has been found to be associated with a poor outlook in cancers of the colon and rectum.

protease

any enzyme that splits proteins, such as PEPSIN, TRYPSIN, EREPSIN or RENNIN.
References in periodicals archive ?
Fungal protease has attracted the attention of experts of environmental biotechnology since fungi can grow on low-cost substrates and secrete huge quantities of the enzyme into the culture medium.
An early stage in the development of industrial fermentation process isolated different organisms for the production of protease in the large-scale (Germano et al., 2003).
Additionally, intestinal digesta contents from the distal end of duodenum to ileo-caecal junction and pancreas samples were collected for protease activity measurement.
89% for males using SBT1; chymotrypsin activity was inhibited by 56% for females and 61% for males when using TPCK; while metal protease activity was inhibited by 85% for females and 95% for males using EDTA, and 75% for females and 83% for males when using phenanthroline; finally, protease activity was inhibited in 62% for females and 75% for males using ovalbumin (Fig.
Structure of HIV-1 Protease. Drugs that are designed to attack HIV-1 protease are among the stellar breakthroughs of modern medicine.
Aspartic protease enzymes from microbial sources are mainly categorized into two groups: (i) the pepsin-like enzymes produced by Aspergillus, Penicillium, Rhizopus, and Neurospora and (ii) the rennin-like enzymes produced by Endothia and Mucor spp., such as Mucor miehei, M.
Upon reaching confluence, the medium was changed to growth factor-free medium, and the plates were incubated for an additional 24 h after which the cells were stimulated with Aspergillus protease for 1 h.
equiseti, and their inhibitory effect on HCV NS3-NS4A protease using a SensoLyte TM 520 HCV protease assay kit.
WOUNDCHEK Protease Status, already available in Europe, Canada & South Africa, detects a chronic inflammatory response in the wound, as indicated by elevated human protease activity (EPA) and was developed to help guide treatment decisions to enable improved outcomes and more cost effective care, added the company.
Doxycycline led to a significant drop in serine protease activity by week 8, compared with baseline and with the placebo group.
Protease production was assessed at 24-h intervals for incubation times up to 72 h.