protamine(redirected from protamine zinc insulin (PZI))
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Related to protamine zinc insulin (PZI): protamine zinc insulin suspension
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.
Farlex Partner Medical Dictionary © Farlex 2012
protamine(prō′tə-mēn′, -mĭn) also
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012