protamine sulphate

An antidote to the anticiagulant HEPARIN. The drug is on the WHO official list. A brand name is Prosulf.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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At CPB weaning off, protamine sulphate was administered (1mg/100 units heparin) to reverse the heparin, targeted to bring the ACT back to 80-120 seconds.

Topical use of tranexamic acid in open heart surgery

Though it includes specific agent like protamine sulphate, it is less effective.

Interesting case of iatrogenic haemothorax

* One intravenous (IV) dose of protamine sulphate can neutralise about 60-75% of the anti-Xa activity.

Recommendations for the anticoagulation of pregnant patients with mechanical heart valves

1.0% solution of protamine sulphate on 0.1 M phosphate buffer pH 7.5

Role of a body's proteinase-inhibitory system at grippe

After 4-48 h incubation with 25 g Fe/ml TA-(USPIO) target cells demonstrated a significant reduction in T2 values.2223 Subsequent work has optimized this method by mixing Ferumoxides with protamine sulphate (50:3) g/ml.

MRI tracking stem cells transplantation for coronary heart disease

Protamine sulphate can be used to reverse the effects of heparin but is associated with anaphylactic reactions and pulmonary hypertension [6, 7].

Systemic heparinisation in laparoscopic live donor nephrectomy

Re-calcified kaolin activated TEG was performed on the citrated blood samples, using native cuvettes, heparinase-modified cuvettes and native cuvettes with the addition of two different doses of protamine sulphate (20 U, 0.5 U, Valeant Pharmaceuticals Germany GMBH, Eschborn, Germany).

Hypocoagulation state in severe systemic inflammatory response syndrome/sepsis is consistent with endogenous heparinoid effect as detected by thromboelastography

Regional heparinisation was used with simultaneous infusions of protamine sulphate and heparin.

Renal equipment and access in the 1960s and 70s

After completion of the anastomosis the heparinization was partially reversed with protamine sulphate and the operation was completed with the ACT at 150 sec.

Coronary bypass surgery in essential thrombocytemia / Esansiyel trombositemide koroner baypas cerrahisi

When staff realised their mistake, they administered protamine sulphate, a drug that reverses the effects of heparin.

OUAID'S TWINS FIGHT FOR LIFE AFTER HUGE OVERDOSE BLUNDER

Importantly, Fondaparinux is not reversed by protamine sulphate. (6) Fondaparinux is not yet commercially available for use in South Africa.

Heparin is a widely used drug--just about any health worker will deal with patients on the drug

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