protamine


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Related to protamine: protamine insulin

protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.
References in periodicals archive ?
Blood samples were taken from the arterial line at the following times: before anesthesia induction, 5 minutes after aortic declamping, after protamine administration, and at the 24th hour after the CPB.
Protamine sulfate (PS) was obtained from Eli Lilly (Indianapolis, IN).
Histones and protamine generated a significant signal in both IRMAs.
Analysis of CREM[tau] and protamine expression in male azoospermic testicular tissue: the pathobiological review of spermatogenic arrest [master's thesis].
After uneventful weaning from CPB using both dopamine and noradrenaline, heparin was reversed with protamine 300 mg by slow infusion.
The Chromomycin A3 (CMA3) staining was applied for the evaluation of protamine deficiency, Aniline Blue staining to detect excessive presence of histones; Toluidine Blue and fluorescence Acridine Orange, as a sensitive structural probes, were used for assessing sperm chromatin structure and packaging (23), (32), (33).
The effect could be reproduced by adding heparin to serum, and it was largely blocked in heparin plasma by addition of the heparin antagonist protamine sulfate.
Currently, the reversal of the anticoagulant effect of all heparins is only achieved with protamine sulfate (a problem for patients who react adversely to protamine).
Recent studies have indicated that protamine deficiency and sperm DNA damage are associated with poor ART outcomes (10, 11).
Northampton, United Kingdom TABLE 1 Some drugs used in anaesthesia that contain animal products Propofol Egg lecithin Gelatine based colloids Degraded bovine/porcine bone Heparin Bovine/porcine lung TPN May contain egg protein/animal fat Hyalase Avian Older insulins Porcine/bovine insulin Protamine Fish Aprotinin Bovine lung
And earlier this year Lilly gained approval for Humalog mix 75/25, a combination of insulin lispro protamine and insulin lispro.