protamine

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protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.
References in periodicals archive ?
Protamin duzeylerinin uygun olmasi kromatinin daha siki paketlenmesine ve sonucta da sperm nukleusunun daha fazla stkistullmasma neden olmaktadir.
Bunun yani sira heparin, protamin ve hipoterminin direk olarak trombosit disfonksiyonu yapici etkileri bilinmektedir (2).
Hazir karisimlarin orta etkili kismi daha once NPH insulinlerin yapim tekniginde oldugu gibi protamin sulfat eklenerek gerceklestirilmistir (9).
Bu amacla, kriyopresipitat, taze donmufl plazma, vitamin K, protamin sulfat ve aminokaproik asit verilebilir.
Tenders are invited for Inj Premix Analogue 300 I.U Of 30 Percent Human Insulin Aspart And 70 Percent Insulin Aspart Protamin Protamine In 3 Ml Flex Pen
3.5 Mg Of Insulin Aspart R-Dna Origin 30 Persent As Soluble Insulin Aspart And 70 Persent As Insilin Aspart Protamin Crystals.
Each Ml Contains 25 Persent Insulin Lispro And 75 Persent Insulin Lispro Protamin Suspension.
3.5 Mg Of Insulin Aspart R-Dna Origin 30 Percentage As Soluble Insulin Aspart And 70 Percentage As Insulin Aspart Protamin Crystal.