prostatic intraepithelial neoplasia


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pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a (PIN),

dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with cell crowding, variation in nuclear size and shape, and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with cell crowding, nucleomegaly and nucleolomegaly, and irregular cell spacing.

pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a

(PIN) (pros-tat'ik in-tra-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with variation in nuclear size and shape and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with nucleomegaly, nucleolomegaly, and irregular cell spacing.
References in periodicals archive ?
Do not misinterpret intraductal carcinoma of the prostate as high-grade prostatic intraepithelial neoplasia! Eur Urol.
The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN).
As prostatic intraepithelial neoplasia is a precursor lesion for prostatic carcinoma, it needs to be detected as early as possible.
The significance of a typical adenomatous hyperplasia and prostatic intraepithelial neoplasia for the development of prostate carcinoma.
Patients with more than one prior negative prostate biopsy, a previous diagnosis of prostate cancer, or evidence of high-grade prostatic intraepithelial neoplasia (HGPIN) or atypical small acinar proliferation (ASAP) on the pre-entry biopsy were excluded.
GTx is developing ACAPODENE(R) (toremifene citrate), a selective estrogen receptor modulator, or SERM, in two separate clinical programs in men: first, a pivotal Phase III clinical trial for the treatment of serious side effects of ADT for advanced prostate cancer, and second, a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men with high grade prostatic intraepithelial neoplasia, or PIN.
Investigator David Price, M.D., reported a 48% reduction in prostate cancer risk for high-grade prostatic intraepithelial neoplasia (PIN) patients who took 20 mg of toremifene each day for a full year.
Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker.
Conversely, common premalignant and malignant cribriform lesions include high-grade prostatic intraepithelial neoplasia (HGPIN) and the cribriform pattern of invasive acinar adenocarcinoma (Gleason pattern 4), respectively, and less common entities, though still clinically important, are ductal adenocarcinoma and intraductal carcinoma of the prostate (IDC-P).